PCR 诊断卡氏肺孢子虫肺炎：双变量荟萃分析。
PCR diagnosis of Pneumocystis pneumonia: a bivariate meta-analysis.
机构信息
Department of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
出版信息
J Clin Microbiol. 2011 Dec;49(12):4361-3. doi: 10.1128/JCM.06066-11. Epub 2011 Oct 19.
Abstract
We undertook a bivariate meta-analysis to assess the overall accuracy of respiratory specimen PCR assays for diagnosing Pneumocystis pneumonia. The summary sensitivity and specificity were 0.99 (95% confidence interval, 0.96 to 1.00) and 0.90 (0.87 to 0.93). Subgroup analyses showed that quantitative PCR analysis and the major surface glycoprotein gene target had the highest specificity value (0.93). Respiratory specimen PCR results are sufficient to confirm or exclude the disease for at-risk patients suspected of having Pneumocystis pneumonia.
摘要
我们进行了双变量荟萃分析，以评估用于诊断肺孢子菌肺炎的呼吸道标本 PCR 检测的总体准确性。汇总敏感性和特异性分别为 0.99（95%置信区间，0.96 至 1.00）和 0.90（0.87 至 0.93）。亚组分析显示，定量 PCR 分析和主要表面糖蛋白基因靶标具有最高的特异性值（0.93）。呼吸道标本 PCR 结果足以确认或排除疑似患有肺孢子菌肺炎的高危患者的疾病。
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