Centre for Lipid Research, Indian Institute of Chemical Technology, Hyderabad, India.
Food Chem. 2013 Jan 1;136(1):259-65. doi: 10.1016/j.foodchem.2012.07.116. Epub 2012 Aug 7.
The hypocholesterolemic effects of two low calorie structured lipids (SL1 and SL2) containing essential fatty acids, prepared by lipase catalysed interesterification of ethyl behenate respectively with sunflower and soybean oils were studied in rats and rabbits. The feeding experiment conducted on rats as well as rabbits, fed on normal and atherogenic diet containing 10% of SL1 and SL2 (experimental) and sunflower oil (control) indicated no adverse effects on growth and food intake. However, the structured lipids beneficially lowered serum and liver lipids, particularly cholesterol, LDL cholesterol, triglycerides and also maintains the essential fatty acid status in serum and liver. The lipid deposition observed in the arteries of rabbits fed on atherogenic diets was significantly reduced when structured lipids were included in the diet. These observations coincided with reduced levels of serum cholesterol particularly LDL cholesterol observed in experimental groups. Therefore the structured lipids, designed to have low calorific value also beneficially lower serum lipids and lipid deposition in animals fed on atherogenic diets.
两种含有必需脂肪酸的低热量结构脂质（SL1 和 SL2）通过脂肪酶催化的分别用乙基山嵛酸与葵花籽油和大豆油的酯交换反应制备，研究了其在大鼠和兔中的降胆固醇作用。在大鼠和兔子的喂养实验中，用正常和含 10%SL1 和 SL2（实验组）和葵花籽油（对照组）的动脉粥样硬化饮食喂养，结果表明对生长和食物摄入没有不良影响。然而，结构脂质有益地降低了血清和肝脏脂质，特别是胆固醇、LDL 胆固醇、甘油三酯，并且还维持了血清和肝脏中的必需脂肪酸状态。当在饮食中包含结构脂质时，用动脉粥样硬化饮食喂养的兔子的动脉中观察到的脂质沉积明显减少。这些观察结果与在实验组中观察到的血清胆固醇特别是 LDL 胆固醇水平降低相吻合。因此，设计具有低热量值的结构脂质也有益于降低动物摄入动脉粥样硬化饮食后的血清脂质和脂质沉积。
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