Internal Medicine, Allergology and Clinical Immunology Unit, Antalya Education and Research Hospital, Antalya, Turkey.
Med Sci Monit. 2012 Oct;18(10):CR617-21. doi: 10.12659/msm.883488.
Allergic rhinitis is a common health problem affecting the immune system. The homeostasis of the immune system is regulated by apoptosis. In this study, serum circulating soluble TRAIL levels of allergic rhinoconjunctivitis patients before and after allergen-specific immunotherapy were evaluated.
MATERIAL/METHODS: The sTRAIL levels of pre- and post-treated allergic rhinoconjunctivitis patients (n=25) were compared to age- and sex-matched healthy individuals (n=25). sTRAIL levels were measured by ELISA. The skin prick test (SPT) results were recorded before and after treatment.
The sTRAIL levels between the pre-treated and control groups were significantly different (p<0.0001). However, there was no significant difference between the post-treated group and healthy individuals (p=0,801). SPT was a statistically significant difference between the values of the research group before and after immunotherapy (grasses mixture, barley mixture, Oleaauropeae, D. Pteronyssinus, D. farinae).
The sTRAIL levels were decreased after allergen-specific immunotherapy to healthy levels and may be of use as a marker of efficacy of immunotherapy in allergic rhinoconjunctivitis patients.
变应性鼻炎是一种常见的影响免疫系统的健康问题。免疫系统的动态平衡受细胞凋亡调节。在这项研究中，评估了变应性鼻结膜炎患者在变应原特异性免疫治疗前后血清中循环可溶性 TRAIL 水平。
材料/方法：将治疗前后的变应性鼻结膜炎患者（n=25）的 sTRAIL 水平与年龄和性别匹配的健康个体（n=25）进行比较。通过 ELISA 测量 sTRAIL 水平。记录治疗前后的皮肤点刺试验（SPT）结果。
治疗前组与对照组之间的 sTRAIL 水平差异有统计学意义（p<0.0001）。然而，治疗后组与健康个体之间无显著差异（p=0.801）。SPT 在免疫治疗前后的研究组之间有统计学显著差异（草混合物、大麦混合物、橄榄属、D. Pteronyssinus、D. farinae）。
变应原特异性免疫治疗后 sTRAIL 水平降低至健康水平，可能作为变应性鼻结膜炎患者免疫治疗疗效的标志物。
