基于 NHANES 2001 至 2002 年的尿硝酸盐、硫氰酸盐、高氯酸盐和血清甲状腺终点。
Urinary nitrate, thiocyanate, and perchlorate and serum thyroid endpoints based on NHANES 2001 to 2002.
机构信息
Intertox, Inc., Seattle, WA 98101, USA.
出版信息
J Occup Environ Med. 2013 Jan;55(1):52-8. doi: 10.1097/JOM.0b013e31826bb774.
OBJECTIVE
To determine, on the basis of iodide uptake inhibition (IUI), whether associations between urinary concentrations of IUI agents (perchlorate, nitrate, and thiocyanate), as total perchlorate equivalent concentration (PEC), and serum thyroid parameters suggest functional thyroid abnormalities. Additional thyroid hormone measures were released to augment the National Health and Examination Survey (NHANES) 2001 to 2002 data set, which we used in this study.
METHODS
Enhanced thyroid hormone measures released to augment the National Health and Examination Survey (NHANES) 2001-2002 data set were used in this study. Multiple regression was used to assess the relationships among total thyroxine (TT4), free thyroxine, total triiodothyronine (TT3), free triiodothyronine, and thyroid- stimulating hormone (TSH) and PEC.
RESULTS
PEC was weakly and negatively associated with TT4, but not with TSH, TT3, or free hormone. This association with TT4 appears to be dominated by nitrate and thiocyanate.
CONCLUSION
No evidence of functional thyroid abnormality (eg., low thyroid hormone coupled with high TSH) was seen with exposure to the combined IUI agents and enhanced estimates of thyroid function.
目的
基于碘摄取抑制（IUI）来确定，尿液中 IUI 剂（高氯酸盐、硝酸盐和硫氰酸盐）的浓度，作为总高氯酸盐当量浓度（PEC），与血清甲状腺参数之间的关联是否提示存在甲状腺功能异常。本研究中使用了为扩充 2001 至 2002 年国家健康与营养检查调查（NHANES）数据而发布的额外甲状腺激素测量值。
方法
本研究使用了为扩充 2001 至 2002 年国家健康与营养检查调查（NHANES）数据而发布的增强型甲状腺激素测量值。多元回归用于评估总甲状腺素（TT4）、游离甲状腺素、总三碘甲状腺原氨酸（TT3）、游离三碘甲状腺原氨酸和促甲状腺激素（TSH）与 PEC 之间的关系。
结果
PEC 与 TT4 呈弱负相关，但与 TSH、TT3 或游离激素无关。与 TT4 的这种关联似乎主要由硝酸盐和硫氰酸盐引起。
结论
在接触联合 IUI 剂和增强型甲状腺功能估计值的情况下，未发现甲状腺功能异常（例如，甲状腺激素低而 TSH 高）的证据。
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