环境中高氯酸盐暴露：对甲状腺的潜在不良影响。
Environmental perchlorate exposure: potential adverse thyroid effects.
作者信息
Leung Angela M, Pearce Elizabeth N, Braverman Lewis E
机构信息
aDivision of Endocrinology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California bSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):372-6. doi: 10.1097/MED.0000000000000090.
Abstract
PURPOSE OF REVIEW
This review will present a general overview of the sources, human studies, and proposed regulatory action regarding environmental perchlorate exposure.
RECENT FINDINGS
Some recent studies have reported significant associations between urinary perchlorate concentrations, thyroid dysfunction, and decreased infant intelligence quotient in groups who would be particularly susceptible to perchlorate effects. An update regarding the recently proposed regulatory actions and potential costs surrounding amelioration of perchlorate contamination is provided.
SUMMARY
The potential adverse thyroidal effects of environmental perchlorate exposure remain controversial, and further research is needed to further define its relationship to human health among pregnant and lactating women and their infants.
摘要
综述目的
本综述将概述环境中高氯酸盐暴露的来源、人体研究及拟采取的监管行动。
最新发现
一些近期研究报告称，在对高氯酸盐影响特别敏感的人群中，尿中高氯酸盐浓度、甲状腺功能障碍与婴儿智商降低之间存在显著关联。本文提供了有关最近提议的监管行动以及高氯酸盐污染治理潜在成本的最新情况。
总结
环境中高氯酸盐暴露对甲状腺的潜在不良影响仍存在争议，需要进一步研究以进一步明确其与孕妇、哺乳期妇女及其婴儿健康之间的关系。
相似文献
1
Environmental perchlorate exposure: potential adverse thyroid effects.环境中高氯酸盐暴露：对甲状腺的潜在不良影响。
Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):372-6. doi: 10.1097/MED.0000000000000090.
2
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women.泰国孕早期女性中高氯酸盐和硫氰酸盐暴露与甲状腺功能之间的关联。
J Clin Endocrinol Metab. 2014 Jul;99(7):2365-71. doi: 10.1210/jc.2013-3986. Epub 2014 Apr 4.
3
CO-occurring exposure to perchlorate, nitrate and thiocyanate alters thyroid function in healthy pregnant women.同时接触高氯酸盐、硝酸盐和硫氰酸盐会改变健康孕妇的甲状腺功能。
Environ Res. 2015 Nov;143(Pt A):1-9. doi: 10.1016/j.envres.2015.09.013. Epub 2015 Sep 25.
4
Perchlorate, iodine and the thyroid.高氯酸盐、碘与甲状腺
Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):133-41. doi: 10.1016/j.beem.2009.08.009.
5
Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period.孕期及新生儿期通过饮用水长期环境暴露于高氯酸盐与甲状腺功能的关系。
Thyroid. 2005 Sep;15(9):963-75. doi: 10.1089/thy.2005.15.963.
6
Maternal perchlorate exposure in pregnancy and altered birth outcomes.孕期母体高氯酸盐暴露与出生结局改变
Environ Res. 2017 Oct;158:72-81. doi: 10.1016/j.envres.2017.05.030. Epub 2017 Jun 9.
7
The epidemiology of environmental perchlorate exposure and thyroid function: a comprehensive review.环境高氯酸盐暴露与甲状腺功能的流行病学：综合评述。
J Occup Environ Med. 2010 Jun;52(6):653-60. doi: 10.1097/JOM.0b013e3181e31955.
8
Effect of environmental perchlorate on thyroid function in pregnant women from Córdoba, Argentina, and Los Angeles, California.阿根廷科尔多瓦和加利福尼亚州洛杉矶孕妇环境中超标的影响。
Endocr Pract. 2011 May-Jun;17(3):412-7. doi: 10.4158/EP10293.OR.
9
Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women.孕早期妇女中高氯酸盐和硫氰酸盐暴露与甲状腺功能。
J Clin Endocrinol Metab. 2010 Jul;95(7):3207-15. doi: 10.1210/jc.2010-0014. Epub 2010 Apr 28.
10
Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California.加利福尼亚州南部女性孕期甲状腺激素与中等剂量高氯酸盐暴露
Environ Health Perspect. 2016 Jun;124(6):861-7. doi: 10.1289/ehp.1409614. Epub 2015 Oct 20.
引用本文的文献
1
Key Messages of the Iodine Deficiency Working Group (AKJ): Maternal Hypothyroxinemia Due to Iodine Deficiency and Endocrine Disruptors as Risks for Child Neurocognitive Development.碘缺乏工作组（AKJ）的关键信息：碘缺乏和内分泌干扰物导致的母体甲状腺素血症是儿童神经认知发育的风险因素。
Geburtshilfe Frauenheilkd. 2025 Mar 26;85(8):796-809. doi: 10.1055/a-2505-1944. eCollection 2025 Aug.
2
A Community-Engaged Oral History Study as a Tool for Understanding Environmental Justice Aspects of Human Exposures to Hazardous Waste Thermal Treatment Emissions in Colfax, LA.一项社区参与的口述历史研究，作为理解路易斯安那州科尔法克斯市人类接触危险废物热处理排放的环境正义问题的工具。
Environ Justice. 2024 Aug;17(4):267-278. doi: 10.1089/env.2023.0003. Epub 2023 Oct 18.
3
Associations of Perchlorate, Nitrate, and Thiocyanate with Bone Mineral Density in the US General Population: A Multi-Cycle Study of NHANES 2011-2018.美国一般人群中高氯酸盐、硝酸盐和硫氰酸盐与骨密度的关联：NHANES 2011-2018 多周期研究。
Nutrients. 2024 Aug 11;16(16):2658. doi: 10.3390/nu16162658.
4
Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption.与微聚合物相关的增塑剂对内分泌干扰的有害后果。
Mater Today Bio. 2024 Jun 24;27:101139. doi: 10.1016/j.mtbio.2024.101139. eCollection 2024 Aug.
5
Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid.外源性褪黑素可保护甲状腺免受某些钠/碘同向转运体抑制剂引起的膜脂质氧化损伤。
Antioxidants (Basel). 2023 Aug 29;12(9):1688. doi: 10.3390/antiox12091688.
6
Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review.碘缺乏、母体甲状腺功能减退症和影响胎儿大脑发育的内分泌干扰物：范围综述。
Nutrients. 2023 May 9;15(10):2249. doi: 10.3390/nu15102249.
7
Perchlorate, nitrate, and thiocyanate: Environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health.高氯酸盐、硝酸盐和硫氰酸盐：环境相关的 NIS 抑制剂污染物及其对甲状腺功能和人类健康的影响。
Front Endocrinol (Lausanne). 2022 Oct 21;13:995503. doi: 10.3389/fendo.2022.995503. eCollection 2022.
8
The Role of Iodine for Thyroid Function in Lactating Women and Infants.哺乳期妇女和婴儿的甲状腺功能的碘作用。
Endocr Rev. 2022 May 12;43(3):469-506. doi: 10.1210/endrev/bnab029.
9
The risk of perchlorate and iodine on the incidence of thyroid tumors and nodular goiter: a case-control study in southeastern China.高氯酸盐和碘对甲状腺肿瘤和结节性甲状腺肿发病风险的影响：中国东南部的一项病例对照研究。
Environ Health. 2022 Jan 4;21(1):4. doi: 10.1186/s12940-021-00818-8.
10
Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.环境因素对促甲状腺激素和甲状腺激素水平的影响。
Int J Mol Sci. 2021 Jun 17;22(12):6521. doi: 10.3390/ijms22126521.
本文引用的文献
1
Occurrence of perchlorate and thiocyanate in human serum from e-waste recycling and reference sites in Vietnam: association with thyroid hormone and iodide levels.越南电子废物回收和参照点人体血清中高氯酸盐和硫氰酸盐的出现：与甲状腺激素和碘水平的关联。
Arch Environ Contam Toxicol. 2014 Jul;67(1):29-41. doi: 10.1007/s00244-014-0021-y. Epub 2014 Apr 10.
2
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women.泰国孕早期女性中高氯酸盐和硫氰酸盐暴露与甲状腺功能之间的关联。
J Clin Endocrinol Metab. 2014 Jul;99(7):2365-71. doi: 10.1210/jc.2013-3986. Epub 2014 Apr 4.
3
The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys.2001 - 2002年和2007 - 2008年美国国家健康与营养检查调查中，高氯酸盐、硝酸盐和硫氰酸盐对潜在敏感亚人群游离甲状腺素的影响。
J Expo Sci Environ Epidemiol. 2014 Nov;24(6):579-87. doi: 10.1038/jes.2013.67. Epub 2013 Oct 23.
4
Contribution of tap water to chlorate and perchlorate intake: a market basket study.自来水中氯酸盐和高氯酸盐摄入的贡献：一项市场篮子研究。
Sci Total Environ. 2013 Oct 1;463-464:199-208. doi: 10.1016/j.scitotenv.2013.05.097. Epub 2013 Jun 24.
5
Impact of pregnancy and other factors on the levels of urinary perchlorate, thiocyanate, and nitrate among females aged 15-44 years: data from National Health and Nutrition Examination Survey: 2003-2008.15-44 岁女性尿中高氯酸盐、硫氰酸盐和硝酸盐水平受妊娠和其他因素的影响：来自 2003-2008 年全国健康和营养调查的数据。
Chemosphere. 2013 May;91(7):882-7. doi: 10.1016/j.chemosphere.2013.02.040. Epub 2013 Mar 19.
6
Combined effects of perchlorate, thiocyanate, and iodine on thyroid function in the National Health and Nutrition Examination Survey 2007-08.2007-2008 年全国健康与营养调查中高氯酸盐、硫氰酸盐和碘联合对甲状腺功能的影响。
Environ Res. 2013 May;123:17-24. doi: 10.1016/j.envres.2013.01.005. Epub 2013 Mar 7.
7
Relative source contributions for perchlorate exposures in a lactating human cohort.在一个哺乳期人类队列中，高氯酸盐暴露的相对来源贡献。
Sci Total Environ. 2013 Jan 15;443:939-43. doi: 10.1016/j.scitotenv.2012.11.072. Epub 2012 Dec 18.
8
Urinary perchlorate as a measure of dietary and drinking water exposure in a representative sample of the United States population 2001-2008.2001-2008 年美国代表性人群饮食和饮水暴露的尿高氯酸盐测量。
J Expo Sci Environ Epidemiol. 2013 Mar;23(2):207-14. doi: 10.1038/jes.2012.108. Epub 2012 Nov 28.
9
Monitoring of perchlorate in diverse foods and its estimated dietary exposure for Korea populations.监测多种食品中的高氯酸盐及其在韩国人群中的估计膳食暴露量。
J Hazard Mater. 2012 Dec;243:52-8. doi: 10.1016/j.jhazmat.2012.09.037. Epub 2012 Sep 24.
10
Perchlorate concentrations in Boston's Charles River after the July 4th fireworks spectacular.7月4日烟花盛会后波士顿查尔斯河中的高氯酸盐浓度。
Thyroid. 2013 Mar;23(3):378-9. doi: 10.1089/thy.2012.0410. Epub 2013 Feb 19.
Zotero 插件