Leung Angela M, Pearce Elizabeth N, Braverman Lewis E
aDivision of Endocrinology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California bSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA.
Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):372-6. doi: 10.1097/MED.0000000000000090.
This review will present a general overview of the sources, human studies, and proposed regulatory action regarding environmental perchlorate exposure.
Some recent studies have reported significant associations between urinary perchlorate concentrations, thyroid dysfunction, and decreased infant intelligence quotient in groups who would be particularly susceptible to perchlorate effects. An update regarding the recently proposed regulatory actions and potential costs surrounding amelioration of perchlorate contamination is provided.
The potential adverse thyroidal effects of environmental perchlorate exposure remain controversial, and further research is needed to further define its relationship to human health among pregnant and lactating women and their infants.
本综述将概述环境中高氯酸盐暴露的来源、人体研究及拟采取的监管行动。
一些近期研究报告称，在对高氯酸盐影响特别敏感的人群中，尿中高氯酸盐浓度、甲状腺功能障碍与婴儿智商降低之间存在显著关联。本文提供了有关最近提议的监管行动以及高氯酸盐污染治理潜在成本的最新情况。
环境中高氯酸盐暴露对甲状腺的潜在不良影响仍存在争议，需要进一步研究以进一步明确其与孕妇、哺乳期妇女及其婴儿健康之间的关系。
