Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Clin Transl Med. 2024 Jul;14(7):e1761. doi: 10.1002/ctm2.1761.
The anti-tumour and tumour-promoting roles of B cells in the tumour microenvironment (TME) have gained considerable attention in recent years. As essential orchestrators of humoral immunity, B cells potentially play a crucial role in anti-tumour therapies. Chemotherapy, a mainstay in cancer treatment, influences the proliferation and function of diverse B-cell subsets and their crosstalk with the TME. Modulating B-cell function by targeting B cells or their associated cells may enhance chemotherapy efficacy, presenting a promising avenue for future targeted therapy investigations.
This review explores the intricate interplay between chemotherapy and B cells, underscoring the pivotal role of B cells in chemotherapy treatment. We summarise promising B-cell-related therapeutic targets, illustrating the immense potential of B cells in anti-tumour therapy. Our work lays a theoretical foundation for harnessing B cells in chemotherapy and combination strategies for cancer treatment.
Chemotherapy can inhibit B-cell proliferation and alter subset distributions and functions, including factor secretion, receptor signalling, and costimulation. Chemotherapy can modulate complex B-cell-T-cell interactions with variable effects on anti-tumour immunity. Targeting B-cell surface markers or signalling improves chemotherapy responses, blocks immune evasion and inhibits tumour growth. Critical knowledge gaps remain regarding B-cell interactions in TME, B-cell chemoresistance mechanisms, TLS biology, heterogeneity, spatial distributions, chemotherapy drug selection and B-cell targets that future studies should address.
近年来，B 细胞在肿瘤微环境（TME）中的抗肿瘤和促肿瘤作用引起了相当大的关注。作为体液免疫的重要协调者，B 细胞在抗肿瘤治疗中可能发挥关键作用。化疗作为癌症治疗的主要手段，影响着各种 B 细胞亚群的增殖和功能及其与 TME 的相互作用。通过靶向 B 细胞或其相关细胞来调节 B 细胞功能，可能会提高化疗疗效，为未来的靶向治疗研究提供有前景的途径。
本综述探讨了化疗与 B 细胞之间的复杂相互作用，强调了 B 细胞在化疗治疗中的关键作用。我们总结了有前途的 B 细胞相关治疗靶点，阐明了 B 细胞在抗肿瘤治疗中的巨大潜力。我们的工作为利用 B 细胞进行化疗和联合治疗癌症策略奠定了理论基础。
化疗可抑制 B 细胞增殖，并改变亚群分布和功能，包括因子分泌、受体信号转导和共刺激。化疗可调节 B 细胞与 T 细胞的复杂相互作用，对抗肿瘤免疫产生不同的影响。靶向 B 细胞表面标志物或信号转导可提高化疗反应、阻断免疫逃逸和抑制肿瘤生长。目前仍存在一些关键的知识空白，包括 TME 中 B 细胞相互作用、B 细胞化疗耐药机制、生发中心 T 细胞样结构（TLS）生物学、异质性、空间分布、化疗药物选择和 B 细胞靶点，未来的研究应重点关注这些问题。
