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Cancer metabolism: When more is less.

作者信息

Jiang Lei, Deberardinis Ralph J

出版信息

Nature. 2012 Sep 27;489(7417):511-2. doi: 10.1038/489511a.

DOI:10.1038/489511a
PMID:23018962
Abstract
摘要

相似文献

1
Cancer metabolism: When more is less.癌症代谢：多即是少。
Nature. 2012 Sep 27;489(7417):511-2. doi: 10.1038/489511a.
2
Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells.肿瘤特异性丙酮酸激酶同工酶M2参与肿瘤细胞能量产生的生化策略。
Acta Biochim Pol. 1997;44(4):711-24.
3
Competition for ADP between pyruvate kinase and mitochondrial oxidative phosphorylation as a control mechanism in glycolysis.
Eur J Biochem. 1974 Jul 1;46(1):133-40. doi: 10.1111/j.1432-1033.1974.tb03605.x.
4
Regulatory properties of three human pyruvate kinases.
Enzyme. 1974;17(5):297-306. doi: 10.1159/000459340.
5
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis.丙酮酸激酶同工酶M2在控制细胞周期进程和肿瘤发生中的非代谢功能
Chin J Cancer. 2012 Jan;31(1):5-7. doi: 10.5732/cjc.011.10446. Epub 2011 Dec 23.
6
The effect of fructose on pyruvate kinase activity in isolated hepatocytes. Inhibition by allantoin and alanine.果糖对分离的肝细胞中丙酮酸激酶活性的影响。尿囊素和丙氨酸的抑制作用。
Biochem J. 1982 Oct 15;208(1):171-8. doi: 10.1042/bj2080171.
7
Zinc inhibition of pyruvate kinase of M-type isozyme.锌对M型同工酶丙酮酸激酶的抑制作用。
Biometals. 2017 Jun;30(3):335-340. doi: 10.1007/s10534-017-0009-y. Epub 2017 Mar 14.
8
Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.丙酮酸激酶M敲低通过AMP激活的蛋白激酶诱导的信号传导促进线粒体生物发生、自噬和癌细胞存活。
J Biol Chem. 2017 Sep 15;292(37):15561-15576. doi: 10.1074/jbc.M117.791343. Epub 2017 Aug 4.
9
[Effect of Ca2+ ions on the pyruvate kinase isoenzymes from rabbit kidney cortex].[钙离子对兔肾皮质丙酮酸激酶同工酶的影响]
Vopr Med Khim. 1977 Sep-Oct;23(5):653-7.
10
Q&A: Cancer: clues from cell metabolism.问答：癌症：细胞代谢的线索
Nature. 2010 Jun 3;465(7298):562-4. doi: 10.1038/465562a.

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Autophagy-related biomarkers in preeclampsia: the underlying mechanism, correlation to the immune microenvironment and drug screening.子痫前期相关的自噬生物标志物：潜在机制、与免疫微环境的相关性及药物筛选。
BMC Pregnancy Childbirth. 2024 Jan 2;24(1):1. doi: 10.1186/s12884-023-06211-2.
3
GLUT1 and PKM2 may be useful prognostic predictors in patients with non‑small cell lung cancer following curative R0 resection.

本文引用的文献

1
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.丙酮酸激酶 M2 激活剂促进四聚体形成并抑制肿瘤发生。
Nat Chem Biol. 2012 Oct;8(10):839-47. doi: 10.1038/nchembio.1060.
2
Metabolic regulation of epigenetics.代谢调控表观遗传学。
Cell Metab. 2012 Jul 3;16(1):9-17. doi: 10.1016/j.cmet.2012.06.001.
3
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression.丙酮酸激酶 M2 特异性 siRNA 诱导细胞凋亡和肿瘤消退。
葡萄糖转运蛋白1（GLUT1）和丙酮酸激酶M2（PKM2）可能是根治性R0切除术后非小细胞肺癌患者有用的预后预测指标。
Oncol Lett. 2023 Feb 10;25(3):129. doi: 10.3892/ol.2023.13715. eCollection 2023 Mar.
4
MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer.原发性肺型卵巢神经内分泌癌的微小RNA与代谢谱分析显示其与小细胞肺癌高度相似。
Noncoding RNA. 2022 Sep 25;8(5):64. doi: 10.3390/ncrna8050064.
5
Expression status and prognostic significance of mitochondrial dynamics OPA3 in human ovarian cancer.线粒体动力学 OPA3 在人卵巢癌中的表达状态及预后意义。
Aging (Albany NY). 2022 May 4;14(9):3874-3886. doi: 10.18632/aging.204050.
6
Six Glycolysis-Related Genes as Prognostic Risk Markers Can Predict the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma.六个与糖酵解相关的基因作为预后风险标志物可预测头颈部鳞状细胞癌患者的预后。
Biomed Res Int. 2021 Feb 10;2021:8824195. doi: 10.1155/2021/8824195. eCollection 2021.
7
Role of the mitochondrial stress response in human cancer progression.线粒体应激反应在人类癌症进展中的作用。
Exp Biol Med (Maywood). 2020 May;245(10):861-878. doi: 10.1177/1535370220920558. Epub 2020 Apr 23.
8
Correlation of PKM2 and CD44 Protein Expression with Poor Prognosis in Platinum-Treated Epithelial Ovarian Cancer: A Retrospective Study.PKM2和CD44蛋白表达与铂类治疗的上皮性卵巢癌预后不良的相关性：一项回顾性研究
Cancers (Basel). 2020 Apr 20;12(4):1013. doi: 10.3390/cancers12041013.
9
Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer.线粒体分裂抑制剂（mdivi-1）可降低癌症中的氧化代谢。
Br J Cancer. 2020 Apr;122(9):1288-1297. doi: 10.1038/s41416-020-0778-x. Epub 2020 Mar 9.
10
Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer.肥胖、糖尿病和癌症中失调的线粒体动力学与代谢
Front Endocrinol (Lausanne). 2019 Sep 3;10:570. doi: 10.3389/fendo.2019.00570. eCollection 2019.
J Exp Med. 2012 Feb 13;209(2):217-24. doi: 10.1084/jem.20111487. Epub 2012 Jan 23.
4
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.丙酮酸激酶 M2 是一种受 PHF3 刺激的缺氧诱导因子 1 共激活剂。
Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054.
5
Identification of small molecule inhibitors of pyruvate kinase M2.丙酮酸激酶M2小分子抑制剂的鉴定
Biochem Pharmacol. 2010 Apr 15;79(8):1118-24. doi: 10.1016/j.bcp.2009.12.003. Epub 2009 Dec 11.
6
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.酪氨酸磷酸化抑制 PKM2 以促进瓦博格效应和肿瘤生长。
Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431.
7
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.丙酮酸激酶的M2剪接异构体对癌症代谢和肿瘤生长很重要。
Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734.
8
Pyruvate kinase M2 is a phosphotyrosine-binding protein.丙酮酸激酶M2是一种磷酸酪氨酸结合蛋白。
Nature. 2008 Mar 13;452(7184):181-6. doi: 10.1038/nature06667.
9
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.磷酸代谢物在细胞增殖、能量代谢及肿瘤治疗中的作用。
J Bioenerg Biomembr. 1997 Aug;29(4):315-30. doi: 10.1023/a:1022490512705.