Dandrieux J R S, Noble P-J M, Halladay L J, McLean L, German A J
School of Veterinary Science, University of Liverpool, Neston, Wirral.
J Small Anim Pract. 2013 Mar;54(3):143-8. doi: 10.1111/jsap.12039.
The aim of this study was to determine canine breed predispositions for decreased serum folate or markedly decreased cobalamin concentrations.
Retrospective analysis of samples from dogs that had serum folate and cobalamin concentrations measured, from 1990 to 2002 at the Comparative Gastroenterology Laboratory of Liverpool, were enrolled. A total of 13,069 samples were analysed. Those with trypsin-like immunoreactivity < 5·0 lg/L were excluded, and only breeds with at least 30 individuals tested were further analyzed. Breed predisposition was determined by calculating odds ratios and 95% confidence intervals for hypocobalaminaemia or decreased folate concentration. Significance was tested with a two-sided Fisher's exact test, and the level of statistical significance was set at P<0·05.
A total of 9960 dogs fulfilled the inclusion criteria. Forty breeds contained at least 30 individuals. Predispositions for hypocobalaminaemia were identified in shar peis, Staffordshire bull terriers, German shepherd dogs and mixed breeds. Predispositions for decreased folate concentration were found in golden retrievers and boxers.
Predisposition for marked hypocobalaminaemia and decreased folate concentration differed between breeds. The shar peis had a markedly increased odds ratio for hypocobalaminaemia, as previously reported in North America, but other at-risk breeds were also identified.
本研究旨在确定血清叶酸降低或钴胺素浓度显著降低的犬种易感性。
对1990年至2002年在利物浦比较胃肠病学实验室检测血清叶酸和钴胺素浓度的犬只样本进行回顾性分析。共分析了13069个样本。排除胰蛋白酶样免疫反应性<5.0 lg/L的样本，仅对至少有30只个体进行检测的犬种进一步分析。通过计算钴胺素缺乏血症或叶酸浓度降低的比值比和95%置信区间来确定犬种易感性。采用双侧Fisher精确检验进行显著性检验，统计学显著性水平设定为P<0.05。
共有9960只犬符合纳入标准。40个犬种至少有30只个体。在沙皮犬、斯塔福郡斗牛梗、德国牧羊犬和混种犬中发现了钴胺素缺乏血症的易感性。在金毛寻回犬和拳师犬中发现了叶酸浓度降低的易感性。
不同犬种之间钴胺素显著缺乏血症和叶酸浓度降低的易感性存在差异。如先前在北美报道的那样，沙皮犬钴胺素缺乏血症的比值比显著增加，但也确定了其他有风险的犬种。
