Department of BioMedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
Sci Transl Med. 2012 Sep 26;4(153):153rv10. doi: 10.1126/scitranslmed.3004528.
Biomaterial-associated infections occur on both permanent implants and temporary devices for restoration or support of human functions. Despite increasing use of biomaterials in an aging society, comparatively few biomaterials have been designed that effectively reduce the incidence of biomaterial-associated infections. This review provides design guidelines for infection-reducing strategies based on the concept that the fate of biomaterial implants or devices is a competition between host tissue cell integration and bacterial colonization at their surfaces.
生物材料相关性感染发生于永久性植入物和用于恢复或支持人体功能的临时性装置。尽管在老龄化社会中生物材料的应用日益增加，但设计出能有效降低生物材料相关性感染发生率的生物材料却相对较少。本综述基于生物材料植入物或装置的命运是其表面的宿主组织细胞整合与细菌定植之间竞争的概念，提供了抗感染策略的设计指南。
