Rivadeneira J, Gorustovich A
Interdisciplinary Materials Group-IESIING-UCASAL, INTECIN UBA-CONICET, A4400EDD, Salta, Argentina.
J Appl Microbiol. 2017 Jun;122(6):1424-1437. doi: 10.1111/jam.13393. Epub 2017 May 3.
Most biomaterial-associated infections are caused by opportunistic pathogens and bacteria that are regularly found within the microflora of the implant site. In addition, a biomaterial implant or device remains at risk of infection by hematogenous spread of bacteria disseminated from infections elsewhere in the body or from infected peri-implant tissue in revision surgery. The resulting infections are frequently accompanied by patient morbidity and discomfort and can lead to surgical replacement of the implant after lengthy, unsuccessful attempts to mitigate infections with antibiotic treatments. Therefore, extensive study is aiming to find new infection-resistant antimicrobial biomaterials and coatings for implants and devices to effectively reduce the incidence of biomaterial-associated infections. An overview of the in vitro and in vivo antimicrobial efficacies of the numerous biomaterials currently available is beyond the scope of this review. Herein, we provide a comprehensive review of bioactive glasses as biomaterial delivery systems for antimicrobial agents.
大多数与生物材料相关的感染是由机会性病原体和在植入部位微生物群落中经常发现的细菌引起的。此外，生物材料植入物或装置仍有因身体其他部位感染或翻修手术中植入物周围感染组织传播的细菌经血行播散而感染的风险。由此产生的感染常常伴随着患者的发病和不适，并可能导致在长期使用抗生素治疗未能成功减轻感染后进行植入物的手术更换。因此，广泛的研究旨在寻找用于植入物和装置的新型抗感染抗菌生物材料和涂层，以有效降低与生物材料相关的感染发生率。对目前可用的众多生物材料的体外和体内抗菌效果进行概述超出了本综述的范围。在此，我们对作为抗菌剂生物材料递送系统的生物活性玻璃进行全面综述。
