Roberts-Harry J, Green S H, Willshaw H E
Department of Ophthalmology, Children's Hospital, Ladywood Middleway, Birmingham.
Arch Dis Child. 1990 Jan;65(1):103-6. doi: 10.1136/adc.65.1.103.
Since its first description optic nerve hypoplasia has been identified with increasing frequency, and a range of associated problems have been described. The major neurological and endocrine associations are well established, but those factors that predispose to the development of optic nerve hypoplasia remain unclear. To understand the aetiology of these problems better, and to formulate a management regime, we studied a consecutive series of 40 patients who were divided into three groups. Group 1 (n = 24) had severe bilateral optic nerve hypoplasia; group 2 (n = 10) had mild, bilateral optic nerve hypoplasia; and group 3 (n = 6) had unilateral optic nerve hypoplasia. Previously described aetiological factors (for example, low maternal age or maternal alcohol or drug ingestion) were not present in any of the groups; this removes the need to screen a specific population. It is important that careful neurological and developmental assessments are carried out in children with optic nerve hypoplasia to identify potential disease. The role of imaging is discussed.
自首次被描述以来，视神经发育不全的确诊频率不断增加，并且一系列相关问题也已被描述。主要的神经学和内分泌学关联已得到充分证实，但那些易导致视神经发育不全的因素仍不清楚。为了更好地理解这些问题的病因，并制定一套管理方案，我们研究了连续的40例患者，他们被分为三组。第1组（n = 24）患有严重双侧视神经发育不全；第2组（n = 10）患有轻度双侧视神经发育不全；第3组（n = 6）患有单侧视神经发育不全。之前描述的病因因素（例如，母亲年龄低或母亲饮酒或吸毒）在任何一组中均未出现；这就无需对特定人群进行筛查。对视神经发育不全的儿童进行仔细的神经学和发育评估以识别潜在疾病非常重要。本文还讨论了影像学的作用。
