Liu Huixin, Liao Haibing, Yuan Ke
Forestation Base for State Key Laboratory of Subtropical Forest, Zhejiang Agriculture and Forestry University, Lin'an 311300, China.
Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1963-7.
To study chemical constituents contained in Aeschynanthus moningeriae.
The chemical constituents were separated and purified by column chromatographic methods such as Diaion HP-20, Toyopearl HW-40, Sephadex LH-20, MCI-Gel CHP-20, RP18 and normal phase silica gel. Their structures were identified on the basis of physiochemical property and spectral techniques (1H, 13C-NMR, DEPT, 1H-1H COSY, HSQC, HMBC, HR-MS).
Twelve compounds were separated and identified as 5,7-dihydroxy-8-C-beta-D-glucosyl-chromone (1), 5-hydroxyl-7,4'-dimethoxyl-flavone (2), 2,3,19, 24-tetrahydroxy-urs12-en-28-oic acid (3), 2,3,19, 24-tetrahydroxy-urs-12-en-28-oic acid ester-28-O-beta-D-gucoside (4), 5-hydroxyl-6,4'-dimethoxyl-7-O-[alpha-L-rhamnosyl-(1-->6)]-beta-D-glucopyranosyl-flavone (5), 5,7,3',4'-tetrahydroxy-6-C-beta-D-glucosyl-flavonol (6), 5,7-dihydroxy-6-C-beta-D-glucosyl-flavonones (7), 5,7, 3',4'-tetrahydroxy-6-C-beta-D-glucosyl-dihydroflavonol (8), daucosterol (9), stigmasterol (10), beta-sitosterol (11), and 3-O-beta-D-glucosyl-stigmasterol (12).
Compound 1 is a new compound, while other compounds were separated from this plant for the first time.
研究芒毛苣苔的化学成分。
采用Diaion HP - 20、Toyopearl HW - 40、Sephadex LH - 20、MCI - Gel CHP - 20、RP18及正相硅胶等柱色谱方法对化学成分进行分离纯化。根据理化性质和光谱技术（1H、13C - NMR、DEPT、1H - 1H COSY、HSQC、HMBC、HR - MS）鉴定其结构。
分离鉴定出12个化合物，分别为5,7 - 二羟基 - 8 - C - β - D - 葡萄糖基色酮（1）、5 - 羟基 - 7,4' - 二甲氧基黄酮（2）、2,3,19,24 - 四羟基乌苏 - 12 - 烯 - 28 - 酸（3）、2,3,19,24 - 四羟基乌苏 - 12 - 烯 - 28 - 酸酯 - 28 - O - β - D - 葡萄糖苷（4）、5 - 羟基 - 6,4' - 二甲氧基 - 7 - O - [α - L - 鼠李糖基 - (1→6)] - β - D - 吡喃葡萄糖基黄酮（5）、5,7,3',4' - 四羟基 - 6 - C - β - D - 葡萄糖基黄酮醇（6）、5,7 - 二羟基 - 6 - C - β - D - 葡萄糖基黄酮（7）、5,7,3',4' - 四羟基 - 6 - C - β - D - 葡萄糖基二氢黄酮醇（8）、胡萝卜苷（9）、豆甾醇（10）、β - 谷甾醇（11）和3 - O - β - D - 葡萄糖基豆甾醇（12）。
化合物1为新化合物，其他化合物均为首次从该植物中分离得到。
