[芒毛苣苔中含有的化学成分]

[Chemical constituents contained in Aeschynanthus moningeriae].

作者信息

Liu Huixin, Liao Haibing, Yuan Ke

机构信息

Forestation Base for State Key Laboratory of Subtropical Forest, Zhejiang Agriculture and Forestry University, Lin'an 311300, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1963-7.

PMID:23019879

Abstract

OBJECTIVE

To study chemical constituents contained in Aeschynanthus moningeriae.

METHOD

The chemical constituents were separated and purified by column chromatographic methods such as Diaion HP-20, Toyopearl HW-40, Sephadex LH-20, MCI-Gel CHP-20, RP18 and normal phase silica gel. Their structures were identified on the basis of physiochemical property and spectral techniques (1H, 13C-NMR, DEPT, 1H-1H COSY, HSQC, HMBC, HR-MS).

RESULT

Twelve compounds were separated and identified as 5,7-dihydroxy-8-C-beta-D-glucosyl-chromone (1), 5-hydroxyl-7,4'-dimethoxyl-flavone (2), 2,3,19, 24-tetrahydroxy-urs12-en-28-oic acid (3), 2,3,19, 24-tetrahydroxy-urs-12-en-28-oic acid ester-28-O-beta-D-gucoside (4), 5-hydroxyl-6,4'-dimethoxyl-7-O-[alpha-L-rhamnosyl-(1-->6)]-beta-D-glucopyranosyl-flavone (5), 5,7,3',4'-tetrahydroxy-6-C-beta-D-glucosyl-flavonol (6), 5,7-dihydroxy-6-C-beta-D-glucosyl-flavonones (7), 5,7, 3',4'-tetrahydroxy-6-C-beta-D-glucosyl-dihydroflavonol (8), daucosterol (9), stigmasterol (10), beta-sitosterol (11), and 3-O-beta-D-glucosyl-stigmasterol (12).

CONCLUSION

Compound 1 is a new compound, while other compounds were separated from this plant for the first time.

摘要

目的

研究芒毛苣苔的化学成分。

方法

采用Diaion HP - 20、Toyopearl HW - 40、Sephadex LH - 20、MCI - Gel CHP - 20、RP18及正相硅胶等柱色谱方法对化学成分进行分离纯化。根据理化性质和光谱技术（1H、13C - NMR、DEPT、1H - 1H COSY、HSQC、HMBC、HR - MS）鉴定其结构。

结果

分离鉴定出12个化合物，分别为5,7 - 二羟基 - 8 - C - β - D - 葡萄糖基色酮（1）、5 - 羟基 - 7,4' - 二甲氧基黄酮（2）、2,3,19,24 - 四羟基乌苏 - 12 - 烯 - 28 - 酸（3）、2,3,19,24 - 四羟基乌苏 - 12 - 烯 - 28 - 酸酯 - 28 - O - β - D - 葡萄糖苷（4）、5 - 羟基 - 6,4' - 二甲氧基 - 7 - O - [α - L - 鼠李糖基 - (1→6)] - β - D - 吡喃葡萄糖基黄酮（5）、5,7,3',4' - 四羟基 - 6 - C - β - D - 葡萄糖基黄酮醇（6）、5,7 - 二羟基 - 6 - C - β - D - 葡萄糖基黄酮（7）、5,7,3',4' - 四羟基 - 6 - C - β - D - 葡萄糖基二氢黄酮醇（8）、胡萝卜苷（9）、豆甾醇（10）、β - 谷甾醇（11）和3 - O - β - D - 葡萄糖基豆甾醇（12）。