Luo Yongming, Liu Hua, Yin Xiaoying, Ye Xide, Kang Lijie
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1977-80.
To study active constituents of Macropanax rosthornii in treating rheumatoid arthritis.
Silica gel column chromatography, preparative HPLC and modern spectrum techniques were applied for a systematic study on chemical constituents contained in M. rosthornii.
Twelve compounds were separated from M. rosthornii and identified as serratagenic acid (1), serjanic acid (2), betulinic acid (3), 6beta-hydroxy-3-oxo-olean-12-en-28-oic acid (4), 3-O-alpha-L-arabinopyranosyl serratagenic acid (5), 3-O-alpha-L-arabinopyranosyl serratagenic acid-29-methyl ester (6) , 3-O-alpha-L-arabinopyranosyl serratagenic acid-28-O-beta-D-glucopyranosyl ester (7), scopoletin (8), beta-sitosterol (9), daucosterol (10), 3,4-dihydroxybenzoic acid (11), and stearic acid (12).
Above compounds are separated from M. rosthornii for the first time.
研究刺楸治疗类风湿关节炎的活性成分。
采用硅胶柱色谱、制备型高效液相色谱及现代波谱技术对刺楸中的化学成分进行系统研究。
从刺楸中分离得到12个化合物，分别鉴定为锯齿酸（1）、刺楸酸（2）、桦木酸（3）、6β-羟基-3-氧代齐墩果-12-烯-28-酸（4）、3-O-α-L-阿拉伯吡喃糖基锯齿酸（5）、3-O-α-L-阿拉伯吡喃糖基锯齿酸-29-甲酯（6）、3-O-α-L-阿拉伯吡喃糖基锯齿酸-28-O-β-D-葡萄糖吡喃糖基酯（7）、东莨菪内酯（8）、β-谷甾醇（9）、胡萝卜苷（10）、3,4-二羟基苯甲酸（11）和硬脂酸（12）。
上述化合物均为首次从刺楸中分离得到。
