Gao Shan, Huang Ling-Ling, Wang Xing-Hui, Yu Ting-Ting, Du Su-Ming, Guo Yan-Wei
Department of Pharmacology, College of Basic Medical, Anhui Medical University, Hefei 230032, China.
Zhong Yao Cai. 2012 Apr;35(4):591-5.
To investigate the effects of Xinjierkang on two kidney one clip -induced hypertension and target organ injury in rats.
Two kidney one clip-induced hypertension rats model was established. Rats were divided into control group, model group, Xinjierkang group, and fosinopril group. At the end of 8th w, the hemodynamics indexes were recorded. The cardiac hypertrophy index was expressed as heart weight/body weight (HW/BW), the histological changes of heart, aorta and kidney were investigated by HE and/or Van Gieson stain.
Compared with control group, the heart systolic and diastolic function were impaired, the heart weight index, cardiomyocytes cross section area (CSA), cardiac collagen deposition, vascular remodeling index and glomerulus area were increased markedly in model group rats. Administration of Xinjierkang and fosinopril markedly ameliorated hemodynamic indexes, inhibited the elevation of HW/BW ratio, CSA of cardiomyocytes, vascular remodeling index and glomerulus hypertrophy, decreased collagen deposition in heart.
Xinjierkang has protective effects against two kidney one clip-induced hemodynamic impairment, cardiovascular remodeling and glomerulus hypertrophy in rats.
探讨心竭尔康对两肾一夹诱导的大鼠高血压及靶器官损伤的影响。
建立两肾一夹诱导的高血压大鼠模型。将大鼠分为对照组、模型组、心竭尔康组和福辛普利组。在第8周结束时，记录血流动力学指标。心脏肥大指数用心脏重量/体重（HW/BW）表示，采用苏木精-伊红（HE）和/或范吉森（Van Gieson）染色观察心脏、主动脉和肾脏的组织学变化。
与对照组相比，模型组大鼠心脏收缩和舒张功能受损，心脏重量指数、心肌细胞横截面积（CSA）、心脏胶原沉积、血管重塑指数和肾小球面积明显增加。给予心竭尔康和福辛普利可显著改善血流动力学指标，抑制HW/BW比值、心肌细胞CSA、血管重塑指数和肾小球肥大的升高，减少心脏胶原沉积。
心竭尔康对两肾一夹诱导的大鼠血流动力学损伤、心血管重塑和肾小球肥大具有保护作用。
