Kimura K, LaRosa C A, Blank M A, Jaffe B M
Department of Surgery, State University of New York, Brooklyn 11203.
Ann Surg. 1990 Feb;211(2):158-64. doi: 10.1097/00000658-199002000-00007.
The aim of this study was to determine whether short-segment jejunal allografts maintained the viability and nutritional status of outbred recipient pigs treated with low-dose cyclosporine. The animals were subjected to total small bowel resection (from the ligament of Treitz to the ileocecal valve, approximately 15 m). Short-gut control animals (n = 8) who had no transplant died of malabsorption on day 62.5 +/- 4.1 (mean +/- SEM). Without cyclosporine immunosuppression, recipients (n = 5) of 3 m to 4 m jejunal allografts died of rejection on day 8.8 +/- 0.7. However enterectomized pigs (n = 11) who had segmental jejunal allograft transplants and were treated with cyclosporine (10 mg/kg/day) demonstrated significantly prolonged survival (to day 80.9 +/- 22.3; p less than 0.05). By 180 days after transplant, surviving animals increased their weight by almost 40%. In conclusion short-segment jejunal allografts significantly improved the mortality and morbidity rates from surgically created short bowel syndrome in pigs.
本研究的目的是确定短节段空肠同种异体移植是否能维持接受低剂量环孢素治疗的远交系受体猪的生存能力和营养状况。对动物实施全小肠切除术（从屈氏韧带至回盲瓣，约15米）。未进行移植的短肠对照动物（n = 8）在第62.5 +/- 4.1天（平均值 +/- 标准误）死于吸收不良。在没有环孢素免疫抑制的情况下，接受3米至4米空肠同种异体移植的受体（n = 5）在第8.8 +/- 0.7天死于排斥反应。然而，接受节段性空肠同种异体移植并接受环孢素（10毫克/千克/天）治疗的肠切除猪（n = 11）存活时间显著延长（至第80.9 +/- 22.3天；p < 0.05）。移植后180天，存活动物体重增加了近40%。总之，短节段空肠同种异体移植显著改善了猪手术造成的短肠综合征的死亡率和发病率。
