Craddock G N, Nordgren S R, Reznick R K, Gilas T, Lossing A G, Cohen Z, Stiller C R, Cullen J B, Langer B
Transplantation. 1983 Apr;35(4):284-8. doi: 10.1097/00007890-198304000-00004.
The effect of the new immunosuppressant cyclosporine on survival after total small intestinal allotransplantation (TSIA) was studied in a canine model. Successful TSIA was performed in 34 dogs. Eleven dogs were treated with cyclosporine, 25 mg/kg/day i.m., starting the day before the operation and continuing for four weeks. Thereafter the same dose was given orally. Thirteen dogs were given oral cyclosporine only, 25 mg/kg/day from the day after transplantation. Ten dogs served as controls. The dogs treated with intramuscular and oral cyclosporine survived a mean of 103.8 +/- 39.4 days (mean +/- S.E.M.). The longest survivor died after 432 days. Survival in this group was significantly longer than that of the control dogs, which survived 12.5 +/- 4.6 days. The orally treated dogs survived 30.4 +/- 7.6 days. All control dogs, and seven of the orally treated dogs, but only two of the intramuscularly treated dogs, died of acute rejection. It is concluded that cyclosporine is effective in prolonging survival after TSIA in the dog and reduces the incidence of acute rejection.
在犬类模型中研究了新型免疫抑制剂环孢素对全小肠同种异体移植（TSIA）后存活情况的影响。对34只犬成功进行了TSIA。11只犬从手术前一天开始接受环孢素治疗，剂量为25mg/kg/天，肌肉注射，持续四周。此后给予相同剂量口服。13只犬仅口服环孢素，从移植后第二天开始，剂量为25mg/kg/天。10只犬作为对照。接受肌肉注射和口服环孢素治疗的犬平均存活103.8±39.4天（平均值±标准误）。最长存活者在432天后死亡。该组的存活时间显著长于对照犬，对照犬存活12.5±4.6天。口服治疗的犬存活30.4±7.6天。所有对照犬以及7只口服治疗的犬死于急性排斥反应，但仅2只肌肉注射治疗的犬死于急性排斥反应。结论是环孢素在延长犬TSIA后的存活时间方面有效，并降低了急性排斥反应的发生率。
