一种在哺乳动物和禽类细胞中由热休克及其他应激诱导产生的新型40千道尔顿蛋白。
A novel 40-kDa protein induced by heat shock and other stresses in mammalian and avian cells.
作者信息
Ohtsuka K, Masuda A, Nakai A, Nagata K
机构信息
Department of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
出版信息
Biochem Biophys Res Commun. 1990 Jan 30;166(2):642-7. doi: 10.1016/0006-291x(90)90857-j.
When HeLa cells were exposed to heat shock or other stresses, a 40-kDa protein (p40) was induced in addition to the classical heat shock proteins with molecular sizes of 110-, 90-, 70-, and 47-kDa. The p40 was induced not only by heat shock but by arsenite and 2-azetidine carboxylic acid. Also, it was induced in rat, mouse and chick cells by these stresses. The p40 was a basic protein (pI divided by 9.2) as judged by two-dimensional gel electrophoresis. To our knowledge, p40 is a novel heat shock protein in mammalian and avian cells.
当海拉细胞暴露于热休克或其他应激条件下时，除了分子大小为110 kDa、90 kDa、70 kDa和47 kDa的经典热休克蛋白外，还会诱导产生一种40 kDa的蛋白质（p40）。p40不仅可由热休克诱导产生，还可由亚砷酸盐和2-氮杂环丁烷羧酸诱导产生。此外，在大鼠、小鼠和鸡细胞中，这些应激条件也可诱导p40产生。根据双向凝胶电泳判断，p40是一种碱性蛋白质（等电点为9.2）。据我们所知，p40是哺乳动物和鸟类细胞中的一种新型热休克蛋白。
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