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本文引用的文献

1
miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay.miRNA 介导的基因沉默通过翻译抑制 followed by mRNA 去腺苷酸化和降解。
Science. 2012 Apr 13;336(6078):237-40. doi: 10.1126/science.1215691.
2
Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish.核糖体图谱分析表明，miR-430 在导致 zebrafish 中 mRNA 降解之前降低了翻译。
Science. 2012 Apr 13;336(6078):233-7. doi: 10.1126/science.1215704. Epub 2012 Mar 15.
3
Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA.ZAP 氨基端结构域的结构表明锌指蛋白如何识别复杂的 RNA。
Nat Struct Mol Biol. 2012 Mar 11;19(4):430-5. doi: 10.1038/nsmb.2243.
4
Promoter elements regulate cytoplasmic mRNA decay.启动子元件调节细胞质 mRNA 衰变。
Cell. 2011 Dec 23;147(7):1473-83. doi: 10.1016/j.cell.2011.12.005.
5
Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.锌指抗病毒蛋白通过选择性靶向多剪接病毒 mRNA 进行降解来抑制 HIV-1 感染。
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15834-9. doi: 10.1073/pnas.1101676108. Epub 2011 Aug 29.
6
Upf1 senses 3'UTR length to potentiate mRNA decay.UPF1 通过感知 3'UTR 长度来增强 mRNA 的降解。
Cell. 2010 Oct 29;143(3):379-89. doi: 10.1016/j.cell.2010.10.005.
7
Identification of a dominant negative inhibitor of human zinc finger antiviral protein reveals a functional endogenous pool and critical homotypic interactions.鉴定人锌指抗病毒蛋白的显性负抑制剂揭示了功能性内源性池和关键同源相互作用。
J Virol. 2010 May;84(9):4504-12. doi: 10.1128/JVI.02018-09. Epub 2010 Feb 24.
8
The mechanism of eukaryotic translation initiation and principles of its regulation.真核生物翻译起始的机制与调控原则。
Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27. doi: 10.1038/nrm2838.
9
RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions.RNA 解旋酶 A 调节 HIV-1 的翻译和子代病毒体的感染性。
Nucleic Acids Res. 2010 Mar;38(5):1686-96. doi: 10.1093/nar/gkp1075. Epub 2009 Dec 9.
10
Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.逆转录病毒利用宿主因子对复杂蛋白质组进行翻译控制的机制。
Retrovirology. 2009 Jan 24;6:8. doi: 10.1186/1742-4690-6-8.

翻译后文本：ZAP 介导的 mRNA 降解先于并需要转录抑制。

Translational repression precedes and is required for ZAP-mediated mRNA decay.

机构信息

Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

出版信息

EMBO J. 2012 Nov 5;31(21):4236-46. doi: 10.1038/emboj.2012.271. Epub 2012 Sep 28.

DOI:10.1038/emboj.2012.271
PMID:23023399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3492732/
Abstract

Translational repression and mRNA degradation are two major mechanisms for post-transcriptional regulation of gene expression. The detailed relationship between these two processes is not yet well established. Zinc-finger antiviral protein (ZAP) inhibits the replication of certain viruses, including human immunodeficiency virus 1, by binding directly to specific viral mRNAs and recruiting cellular mRNA degradation machinery to degrade the target mRNA. Here, we report that ZAP also inhibits the translation of target mRNAs by interfering with the interaction between translational initiation factors eIF4G and eIF4A. Furthermore, we provide evidence that translational repression is required for mRNA degradation and that blocking the degradation of target mRNAs does not affect ZAP-mediated translational repression. We conclude that ZAP can both repress translation and promote degradation of target mRNA, and that translational repression precedes and is required for mRNA degradation.

摘要

翻译后文本

翻译后文本

转录抑制和 mRNA 降解是基因表达转录后调控的两种主要机制。这两个过程之间的详细关系尚未得到很好的确定。锌指抗病毒蛋白 (ZAP) 通过直接结合特定的病毒 mRNA 并招募细胞 mRNA 降解机制来降解靶 mRNA，从而抑制某些病毒（包括人类免疫缺陷病毒 1）的复制。在这里，我们报告 ZAP 还通过干扰翻译起始因子 eIF4G 和 eIF4A 之间的相互作用来抑制靶 mRNA 的翻译。此外，我们提供了证据表明翻译抑制对于 mRNA 降解是必需的，并且阻止靶 mRNA 的降解不会影响 ZAP 介导的翻译抑制。我们得出结论，ZAP 可以同时抑制靶 mRNA 的翻译和促进其降解，并且翻译抑制先于并需要 mRNA 降解。