Raekallio J, Hirvonen J, Laaksonen H, Möttönen M, Nikkari T, Pesonen E, Ylä-Herttuala S, Akerblom H K
Department of Forensic Medicine, University of Turku, Finland.
APMIS. 1990 Feb;98(2):137-42. doi: 10.1111/j.1699-0463.1990.tb01013.x.
Coronary arteries of 93 clinically healthy Finnish children of both sexes were collected from successive, medicolegal autopsies of victims of violent death. In the histological and histochemical study, local, cushion-type thickenings of the coronary walls were demonstrable in 47, i.e. 50 per cent, of the children, the occurrence increasing with age. The most prominent change was the splitting of the internal elastic membrane and the accumulation of smooth muscle cells, forming a new, musculo-elastic layer. Glycosaminoglycans appeared in the luminal parts of the thickenings. There was an average decrease in the succinate dehydrogenase reaction in the cushion area, implying a degenerative process. The increase in the reaction of "injury markers", acid phosphatase and esterase based on the increase of cells rich in these enzymes, indicated pathologic process. It was concluded that change of this kind, demonstrable early in childhood, may dispose coronary arteries to atherosclerosis.
从一系列暴力死亡受害者的法医尸检中收集了93名临床健康的芬兰儿童（男女均有）的冠状动脉。在组织学和组织化学研究中，47名儿童（即50%）的冠状动脉壁出现了局部垫状增厚，且这种情况随年龄增长而增加。最显著的变化是内弹性膜分裂和平滑肌细胞积聚，形成新的肌肉弹性层。糖胺聚糖出现在增厚部位的管腔部分。垫状区域的琥珀酸脱氢酶反应平均降低，这意味着存在退行性过程。基于富含这些酶的细胞增加，“损伤标志物”酸性磷酸酶和酯酶的反应增强，表明存在病理过程。得出的结论是，这种在儿童早期就可显示的变化可能会使冠状动脉易于发生动脉粥样硬化。
