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Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.

作者信息

Folk Drew S, Torosian Justin C, Hwang Sunhee, McCafferty Dewey G, Franz Katherine J

机构信息

Department of Chemistry, Duke University, 124 Science Dr. Durham, NC 27708, USA.

出版信息

Angew Chem Int Ed Engl. 2012 Oct 22;51(43):10795-9. doi: 10.1002/anie.201206673. Epub 2012 Sep 28.

DOI:10.1002/anie.201206673
PMID:23023944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3495557/
Abstract
摘要

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J Med Chem. 2011 Aug 25;54(16):5836-57. doi: 10.1021/jm200544q. Epub 2011 Jul 29.
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Aβ oligomer-induced synapse degeneration in Alzheimer's disease.
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A novel two-photon ratiometric fluorescent probe for imaging and sensing of BACE1 in different regions of AD mouse brain.一种用于对阿尔茨海默病小鼠大脑不同区域的β-分泌酶1进行成像和传感的新型双光子比率荧光探针。
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Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency.推测靶向低密度脂蛋白受体相关蛋白1（LRP1）的转运肽在体外将β-分泌酶抑制剂递送至神经元的效率有限。
Sci Rep. 2016 Sep 29;6:34297. doi: 10.1038/srep34297.
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