State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, P R China.
Planta Med. 2012 Nov;78(17):1878-80. doi: 10.1055/s-0032-1315369. Epub 2012 Sep 21.
Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 × 10-5, 4.7 × 10-5, and 5.1 × 10-5 M, respectively.
从滇紫草根部分离得到三个新的倍半萜类化合物dobinin A-C（1-3），以及五个已知化合物。根据光谱分析，包括 1D-、2D-NMR 和 MS 技术，以及与文献中报道的类似化合物的光谱数据进行比较，确定了这三个新化合物的结构。对化合物 1-3 进行了体外抗肿瘤活性筛选，结果表明它们对人肿瘤细胞系 HL-60 具有一定的细胞毒性，IC50 值分别为 8.0×10-5、4.7×10-5 和 5.1×10-5 M。
