一种从滇藏青荚叶中分离得到的新型抗疟降香烷倍半萜类化合物。
A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi.
作者信息
Wu Xiu-Rong, Shen Yi, Cui Shu-Jun, Luo Xiao-Lei, Xiao Chao-Jiang, Jiang Bei
机构信息
Institute of Materia Medica, Dali University, Xueren Road 2, Dali, 671000, People's Republic of China.
College of Pharmacy and Chemistry, Dali University, Xueren Road 2, Dali, 671000, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2020 Apr;10(2):101-104. doi: 10.1007/s13659-020-00234-4. Epub 2020 Feb 24.
One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day.
从云南黄杞去皮根中分离得到一个新的当归酰化去甲乌药烷倍半萜，多宾宁O（1），以及四个已知的桉叶烷倍半萜（2-5）。通过广泛的光谱数据分析阐明了它们的结构。此外，化合物1对约氏疟原虫BY265RFP表现出中等抗疟活性，在剂量为30mg/kg/天时抑制率为17.8±13.3%。
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