Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
J Med Virol. 2013 Jan;85(1):157-70. doi: 10.1002/jmv.23366. Epub 2012 Sep 28.
A rotavirus G1P[8] strain C1-81 was isolated from a 5-month-old female infant admitted to hospital with fever and severe diarrhea in Incheon, South Korea. To investigate its full genomic relatedness and its group, the full genome of strain C1-81 was determined. Based on a full genome classification system, C1-81 was shown to possess the typical Wa-like genotype constellation: G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. On the basis of sequence similarities, the strain was shown to be the closest related strain to contemporary human rotavirus strains with recent strains isolated in Asia. This C1-81 strain showed the highest degree of nucleic acid similarity (98.8% and 97%) to G1 B4633-03 and P[8] (Thai-1604 and Dhaka8-02), respectively. This is the first report that group A rotavirus was analyzed with G1P[8] in South Korea. The study of the complete genome of the virus will help understanding of the evolution of rotavirus.
一株轮状病毒 G1P[8]型 C1-81 株从一名 5 月龄因发热和严重腹泻入住韩国仁川某医院的女婴中分离得到。为了研究其全基因组的相关性及其所属群组，我们对 C1-81 株的全基因组进行了测定。基于全基因组分类系统，C1-81 株具有典型的 Wa 样基因型组成：G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1。根据序列相似性，该分离株与近期在亚洲分离的当代人轮状病毒株最为相近。与 G1 株 B4633-03 和 P[8]株（泰国-1604 和达卡 8-02）相比，该 C1-81 株的核酸相似度最高（分别为 98.8%和 97%）。这是首次在韩国报道分析 A 组轮状病毒 G1P[8]型。对病毒全基因组的研究将有助于了解轮状病毒的进化。
