Mitchell Meghan B, Cimino Cynthia R, Benitez Andreana, Brown Cassandra L, Gibbons Laura E, Kennison Robert F, Shirk Steven D, Atri Alireza, Robitaille Annie, Macdonald Stuart W S, Lindwall Magnus, Zelinski Elizabeth M, Willis Sherry L, Schaie K Warner, Johansson Boo, Dixon Roger A, Mungas Dan M, Hofer Scott M, Piccinin Andrea M
Edith Nourse Rogers Memorial Veterans Hospital, Geriatric Research, Education and Clinical Center, Massachusetts General Hospital, Harvard Medical School, 200 Springs Road, Bedford, MA 01730, USA.
J Aging Res. 2012;2012:461592. doi: 10.1155/2012/461592. Epub 2012 Sep 13.
Engagement in cognitively stimulating activities has been considered to maintain or strengthen cognitive skills, thereby minimizing age-related cognitive decline. While the idea that there may be a modifiable behavior that could lower risk for cognitive decline is appealing and potentially empowering for older adults, research findings have not consistently supported the beneficial effects of engaging in cognitively stimulating tasks. Using observational studies of naturalistic cognitive activities, we report a series of mixed effects models that include baseline and change in cognitive activity predicting cognitive outcomes over up to 21 years in four longitudinal studies of aging. Consistent evidence was found for cross-sectional relationships between level of cognitive activity and cognitive test performance. Baseline activity at an earlier age did not, however, predict rate of decline later in life, thus not supporting the concept that engaging in cognitive activity at an earlier point in time increases one's ability to mitigate future age-related cognitive decline. In contrast, change in activity was associated with relative change in cognitive performance. Results therefore suggest that change in cognitive activity from one's previous level has at least a transitory association with cognitive performance measured at the same point in time.
参与认知刺激活动被认为可以维持或增强认知技能,从而将与年龄相关的认知衰退降至最低。虽然存在一种可改变的行为能够降低认知衰退风险的观点对老年人具有吸引力且可能赋予他们力量,但研究结果并未始终支持参与认知刺激任务的有益效果。通过对自然认知活动的观察性研究,我们在四项衰老纵向研究中报告了一系列混合效应模型,这些模型包括基线和认知活动的变化,用于预测长达21年的认知结果。我们发现了认知活动水平与认知测试表现之间横断面关系的一致证据。然而,早年的基线活动并不能预测晚年的衰退速度,因此不支持在较早时间点参与认知活动会增强一个人减轻未来与年龄相关认知衰退能力的概念。相比之下,活动的变化与认知表现的相对变化相关。因此,结果表明,与之前水平相比,认知活动的变化至少与在同一时间点测量的认知表现存在暂时关联。