Arora Vipin, Nagarkar Nitin M, Dass Arjun, Malhotra Arvind
Government Medical College & Hospital, Chandigarh, India.
Indian J Otolaryngol Head Neck Surg. 2011 Oct;63(4):325-9. doi: 10.1007/s12070-011-0240-8. Epub 2011 Apr 11.
Invasive aspergillosis usually affects immune-compromised patients and is common in diabetics. Proptosis, visual loss and ophthalmoplegia due to intra-orbital extension are common presentations. Three out of five patients in our series were immune-compromised. All the patients had visual loss and three patients presented with unilateral blindness. Three patients were treated by surgical debridement followed by Amphotericin B therapy. Two patients who had intra-cranial extension of the disease died during the treatment. Only one patient had improvement in vision following the treatment. High index of suspicion in immune-compromised patients, early diagnosis and prompt aggressive treatment is required to achieve clinical cure.
侵袭性曲霉病通常影响免疫功能低下的患者，在糖尿病患者中很常见。眼眶内蔓延导致的眼球突出、视力丧失和眼肌麻痹是常见症状。我们系列研究中的五名患者中有三名免疫功能低下。所有患者均有视力丧失，三名患者出现单眼失明。三名患者接受了手术清创，随后接受两性霉素B治疗。两名疾病颅内蔓延的患者在治疗期间死亡。治疗后只有一名患者视力有所改善。对免疫功能低下的患者要有高度的怀疑指数，需要早期诊断并迅速积极治疗才能实现临床治愈。
