Schwartzbaum J S
Department of Psychology, University of Rochester, NY 14627.
Physiol Behav. 1988;44(4-5):507-26. doi: 10.1016/0031-9384(88)90313-7.
Single-unit responses of LH cells and oral reaction were studied in food-deprived animals to intraoral injections of rewarding and aversive tastants differentially cued by tonal stimuli. Correlative tests were carried out with microstimulation. Classification and statistical analysis of task-related neurons in different AP regions of LH revealed two functionally disparate, anatomically segregated groups of cells that may play a role in hedonic reactions to tastants. A rostral group showed strong "excitatory" response to aversive test stimuli and divergent "inhibitory" or minimal response to rewarding test stimuli. More caudal cells displayed maximal excitatory response to rewarding test stimuli, which, in some cases, related to oral behavior. Microstimulation of caudal sites also evoked rhythmical oral movement. Phasic and/or tonic reactivity to taste stimuli were common among LH neurons, but most cells responded differentially to both conditioned stimuli and tastants. Only a few cells reacted selectively to the fluid stimuli.
在食物剥夺的动物中，研究了下丘脑外侧区（LH）细胞的单单位反应和口腔反应，这些动物通过音调刺激对口腔内注射的奖励性和厌恶性味觉刺激进行差异提示。同时进行了微刺激相关测试。对LH不同前脑区域与任务相关神经元的分类和统计分析揭示了两组功能不同、解剖学上分离的细胞，它们可能在对味觉刺激的享乐反应中发挥作用。一组位于前部的细胞对厌恶性测试刺激表现出强烈的“兴奋性”反应，而对奖励性测试刺激表现出不同的“抑制性”或最小反应。更靠后的细胞对奖励性测试刺激表现出最大兴奋性反应，在某些情况下，这与口腔行为有关。对后部区域的微刺激也会诱发有节奏的口腔运动。LH神经元对味觉刺激的相位性和/或紧张性反应很常见，但大多数细胞对条件刺激和味觉刺激的反应不同。只有少数细胞对液体刺激有选择性反应。
