D'Souza M B, Nagarkatti P S, Rao K M
J Hyg Epidemiol Microbiol Immunol. 1979;23(1):59-66.
Sera from twenty patients with clinically diagnosed viral encephalitis were studied during the acute and convalescent phases of illness for evidence of group B arboviral infection by demonstrating a rise in the titre of haemagglutination inhibiting (HI) antibodies. The immune status of these individuals was studied by quantitating peripheral T, T and 'null' lymphocytes. The percentage of total T cells in arboviral encephalitic (AE) group decreased significantly while that of B cells and 'active' T cells remained unaltered when compared to that of normal individuals. The null cell percentage, on the other hand increased significantly in the AE group. The absolute number of circulating T and B cells did not alter in the AE group while that of null cells rose significantly. The percentage and concentration of T. B and null cells during the convalescent phase of AE did not differ significantly when compared to those of the acute phase.
对20例临床诊断为病毒性脑炎的患者在疾病的急性期和恢复期采集血清，通过检测血凝抑制（HI）抗体滴度升高来研究是否存在B组虫媒病毒感染的证据。通过对外周血T细胞、T细胞和“裸”淋巴细胞进行定量分析，研究了这些个体的免疫状态。与正常个体相比，虫媒病毒性脑炎（AE）组的总T细胞百分比显著降低，而B细胞和“活性”T细胞的百分比保持不变。另一方面，AE组的裸细胞百分比显著增加。AE组循环T细胞和B细胞的绝对数量没有变化，而裸细胞的绝对数量显著增加。与急性期相比，AE恢复期T细胞、B细胞和裸细胞的百分比和浓度没有显著差异。
