发育异常痣患者发生恶性黑色素瘤的临床特征。

Clinical characteristics of malignant melanomas developing in persons with dysplastic nevi.

作者信息

Rivers J K, Kopf A W, Vinokur A F, Rigel D S, Friedman R J, Heilman E R, Levenstein M

机构信息

Department of Dermatology, New York University School of Medicine, New York.

出版信息

Cancer. 1990 Mar 1;65(5):1232-6. doi: 10.1002/1097-0142(19900301)65:5<1232::aid-cncr2820650533>3.0.co;2-8.

DOI:10.1002/1097-0142(19900301)65:5<1232::aid-cncr2820650533>3.0.co;2-8

PMID:2302671

Abstract

A total of 452 patients with dysplastic nevi (DN) were followed prospectively by repetitive, complete cutaneous examinations in order to determine the clinical features of early malignant melanomas (MM) arising in them. Sixteen patients (3.5%) developed 18 newly diagnosed MM during an average follow-up period of 27 months. Twelve of the 18 MM were in situ and all of the primary invasive MM diagnosed prospectively in this follow-up were less than 0.89 mm in Breslow thickness, implying an excellent prognosis. The principal clinical clue to the diagnosis of MM was change in a preexisting pigmented lesion. Total-body photographs were very useful in helping to identify the early MM in these patients.

摘要

对总共452例发育异常痣（DN）患者进行了前瞻性随访，通过重复的完整皮肤检查来确定其中发生的早期恶性黑色素瘤（MM）的临床特征。在平均27个月的随访期内，16例患者（3.5%）出现了18例新诊断的MM。18例MM中有12例为原位癌，在本次随访中前瞻性诊断的所有原发性浸润性MM的 Breslow厚度均小于0.89 mm，这意味着预后良好。MM诊断的主要临床线索是既往色素沉着病变的变化。全身照片在帮助识别这些患者的早期MM方面非常有用。