子宫平滑肌瘤中的12号染色体三体。一个新的细胞遗传学亚组。
Trisomy 12 in uterine leiomyomas. A new cytogenetic subgroup.
作者信息
Nilbert M, Heim S, Mandahl N, Flodérus U M, Willén H, Mitelman F
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Cancer Genet Cytogenet. 1990 Mar;45(1):63-6. doi: 10.1016/0165-4608(90)90067-k.
PMID:2302686
Abstract
Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma.
摘要
对子宫平滑肌瘤短期培养物进行的染色体分析显示，6例存在12号染色体三体。在其中4个肿瘤中，+12是唯一的核型改变。第5例还存在4号染色体三体，而第6例除了该异常外，还存在一条X染色体缺失。这些发现表明，12号染色体三体是子宫平滑肌瘤一个新的细胞遗传学亚组的特征。
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