Translocation (1;6)(p12;p23) in ANLL.
作者信息
Jacob A K, Sreekantaiah C, Baer M R, Sandberg A A
机构信息
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
出版信息
Cancer Genet Cytogenet. 1990 Mar;45(1):67-71. doi: 10.1016/0165-4608(90)90068-l.
PMID:2302687
Abstract
We report here a case of acute nonlymphocytic leukemia evolving from a myelodysplastic syndrome which developed in an elderly man who had received radiation therapy for a prior cancer. Cytogenetic analysis revealed the following karyotype: 47,XY, + 8,t(1;6)(p13;p23). The breakpoints in the translocation are in the regions of the NRAS1 and PIM1 oncogenes on chromosomes 1 and 6, respectively. This translocation has not been previously observed in hematological malignancies.
摘要
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