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1
HIV-1 reverse transcription.HIV-1 逆转录。
Cold Spring Harb Perspect Med. 2012 Oct 1;2(10):a006882. doi: 10.1101/cshperspect.a006882.
2
Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication.野生型和齐多夫定耐药型逆转录酶在HIV-1复制过程中对特定核苷酸错配的校正
J Mol Biol. 2016 Jun 5;428(11):2275-2288. doi: 10.1016/j.jmb.2016.04.005. Epub 2016 Apr 10.
3
HIV-1 reverse transcription.HIV-1逆转录
Methods Mol Biol. 2014;1087:55-70. doi: 10.1007/978-1-62703-670-2_6.
4
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.HIV-1 逆转录酶中的 M230L 非核苷逆转录酶抑制剂耐药突变会损害酶的功能和病毒复制能力。
Antimicrob Agents Chemother. 2010 Jun;54(6):2401-8. doi: 10.1128/AAC.01795-09. Epub 2010 Mar 22.
5
Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors.非核苷类逆转录酶抑制剂抑制HIV复制的机制
Virus Res. 2008 Jun;134(1-2):147-56. doi: 10.1016/j.virusres.2008.01.002. Epub 2008 Mar 26.
6
Impact of human immunodeficiency virus type 1 reverse transcriptase inhibitor drug resistance mutation interactions on phenotypic susceptibility.1型人类免疫缺陷病毒逆转录酶抑制剂耐药性突变相互作用对表型易感性的影响
AIDS Res Hum Retroviruses. 2008 Oct;24(10):1291-300. doi: 10.1089/aid.2007.0244.
7
The HIV-1 reverse transcription (RT) process as target for RT inhibitors.作为逆转录酶抑制剂作用靶点的HIV-1逆转录过程
Med Res Rev. 2000 Mar;20(2):129-54. doi: 10.1002/(sici)1098-1128(200003)20:2<129::aid-med2>3.0.co;2-a.
8
A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.HIV-1 CRF08_BC亚型逆转录酶连接子结构域中的一种新型突变D404N赋予了对非核苷类逆转录酶抑制剂（NNRTIs）的交叉耐药性。
J Antimicrob Chemother. 2015 May;70(5):1381-90. doi: 10.1093/jac/dku565. Epub 2015 Jan 29.
9
Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.HIV-1逆转录酶中齐多夫定耐药性突变T215Y、M41L和L210W的分析
Antimicrob Agents Chemother. 2015 Dec;59(12):7184-96. doi: 10.1128/AAC.05069-14. Epub 2015 Aug 31.
10
Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance.不断发展的 HIV-1 逆转录酶结构、功能、抑制和耐药性的认识。
Curr Opin Struct Biol. 2020 Apr;61:113-123. doi: 10.1016/j.sbi.2019.11.011. Epub 2020 Jan 11.
引用本文的文献
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The role of HIV-1 Gag and genomic RNA interactions in virion assembly.HIV-1核衣壳蛋白（Gag）与基因组RNA相互作用在病毒体组装中的作用。
Front Microbiol. 2025 Aug 5;16:1642090. doi: 10.3389/fmicb.2025.1642090. eCollection 2025.
2
How Can Plant-Derived Natural Products and Plant Biotechnology Help Against Emerging Viruses?植物源天然产物和植物生物技术如何助力对抗新出现的病毒？
Int J Mol Sci. 2025 Jul 22;26(15):7046. doi: 10.3390/ijms26157046.
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Profiling HIV1-host protein-protein interaction networks in patient-derived exosome proteins: impact on pathophysiology and innate immune pathways.分析患者来源的外泌体蛋白中HIV-1与宿主的蛋白质-蛋白质相互作用网络：对病理生理学和固有免疫途径的影响。
Virol J. 2025 Jul 28;22(1):259. doi: 10.1186/s12985-025-02717-7.
4
Harnessing Antiviral Peptides: From Molecular Mechanisms to Clinical Translation.利用抗病毒肽：从分子机制到临床转化
Curr Res Pharmacol Drug Discov. 2025 Jul 15;9:100228. doi: 10.1016/j.crphar.2025.100228. eCollection 2025.
5
The role of chromatin in retroviral preintegration complex function.染色质在逆转录病毒整合前复合体功能中的作用。
J Biol Chem. 2025 Jul 3;301(8):110440. doi: 10.1016/j.jbc.2025.110440.
6
Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo.慢病毒载体假型化用于体内细胞特异性基因递送的研究进展
Viruses. 2025 May 31;17(6):802. doi: 10.3390/v17060802.
7
Biomedical Interventions for HIV Prevention and Control: Beyond Vaccination.用于艾滋病毒预防和控制的生物医学干预措施：超越疫苗接种
Viruses. 2025 May 26;17(6):756. doi: 10.3390/v17060756.
8
A Model of Non-Homologous Recombination Mediated by HIV-1 Reverse Transcriptase Explaining Sequence Motif Duplications That Confer a Replication Fitness Advantage.一种由HIV-1逆转录酶介导的非同源重组模型，解释了赋予复制适应性优势的序列基序重复现象。
Viruses. 2025 May 7;17(5):680. doi: 10.3390/v17050680.
9
Involvement of lncRNAs NEAT1 and ZBTB11-AS1 in Active and Persistent HIV-1 Infection in C20 Human Microglial Cell Line.lncRNAs NEAT1和ZBTB11-AS1在C20人小胶质细胞系中参与HIV-1的活跃和持续感染
Int J Mol Sci. 2025 May 15;26(10):4745. doi: 10.3390/ijms26104745.
10
Clicking viruses-with chemistry toward mechanisms in infection.点击病毒——借助化学方法探索感染机制
J Virol. 2025 Jun 17;99(6):e0047125. doi: 10.1128/jvi.00471-25. Epub 2025 May 14.
本文引用的文献
1
HIV: cell binding and entry.HIV：细胞结合与进入。
Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a006866. doi: 10.1101/cshperspect.a006866.
2
HIV-1 assembly, budding, and maturation.HIV-1 组装、出芽和成熟。
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006924. doi: 10.1101/cshperspect.a006924.
3
HIV DNA integration.HIV DNA 整合。
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006890. doi: 10.1101/cshperspect.a006890.
4
HIV Restriction Factors and Mechanisms of Evasion.HIV 限制因子和逃逸机制。
Cold Spring Harb Perspect Med. 2012 May;2(5):a006940. doi: 10.1101/cshperspect.a006940.
5
HIV-1 antiretroviral drug therapy.HIV-1 抗逆转录病毒药物治疗。
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007161. doi: 10.1101/cshperspect.a007161.
6
Structural basis of HIV-1 resistance to AZT by excision.HIV-1 对 AZT 耐药性的结构基础：切除。
Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. doi: 10.1038/nsmb.1908. Epub 2010 Sep 19.
7
Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.HIV-1 复制单轮中产生的突变的性质、位置和频率。
J Virol. 2010 Oct;84(19):9864-78. doi: 10.1128/JVI.00915-10. Epub 2010 Jul 21.
8
Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.具有非核苷类逆转录酶抑制剂耐药突变的 HIV-1 在细胞培养中的适应性降低与病毒粒子中逆转录酶含量和 RNase H 活性的相对水平相关。
J Virol. 2010 Sep;84(18):9377-89. doi: 10.1128/JVI.00618-10. Epub 2010 Jun 30.
9
Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication.HIV-1 重组的体外模式为远距离位点的共同适应提供了证据，导致在复制过程中对亚型间重组体进行纯化选择。
J Virol. 2010 Aug;84(15):7651-61. doi: 10.1128/JVI.00276-10. Epub 2010 May 26.
10
Delineation of the preferences and requirements of the human immunodeficiency virus type 1 dimerization initiation signal by using an in vivo cell-based selection approach.利用基于体内细胞的筛选方法描绘1型人类免疫缺陷病毒二聚化起始信号的偏好性和需求
J Virol. 2010 Jul;84(13):6866-75. doi: 10.1128/JVI.01930-09. Epub 2010 Apr 21.
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