HIV-1 逆转录。
HIV-1 reverse transcription.
机构信息
Viral Recombination Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
出版信息
Cold Spring Harb Perspect Med. 2012 Oct 1;2(10):a006882. doi: 10.1101/cshperspect.a006882.
Abstract
Reverse transcription and integration are the defining features of the Retroviridae; the common name "retrovirus" derives from the fact that these viruses use a virally encoded enzyme, reverse transcriptase (RT), to convert their RNA genomes into DNA. Reverse transcription is an essential step in retroviral replication. This article presents an overview of reverse transcription, briefly describes the structure and function of RT, provides an introduction to some of the cellular and viral factors that can affect reverse transcription, and discusses fidelity and recombination, two processes in which reverse transcription plays an important role. In keeping with the theme of the collection, the emphasis is on HIV-1 and HIV-1 RT.
摘要
逆转录和整合是逆转录病毒科的定义特征；“逆转录病毒”这一通用名称源于这样一个事实，即这些病毒使用病毒编码的酶，逆转录酶（RT），将其 RNA 基因组转化为 DNA。逆转录是逆转录病毒复制的一个重要步骤。本文概述了逆转录，简要描述了 RT 的结构和功能，介绍了一些可能影响逆转录的细胞和病毒因素，并讨论了保真度和重组，这两个过程中逆转录都起着重要作用。与本专题集的主题保持一致，重点是 HIV-1 和 HIV-1 RT。
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