Lupus Clinic, Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.
PLoS One. 2012;7(9):e45934. doi: 10.1371/journal.pone.0045934. Epub 2012 Sep 21.
Several indices have been proposed to assess disease activity in patients with Systemic Lupus Erythematosus (SLE). Recent studies have showed a prevalence of flare between 28-35.3%, persistently active disease (PAD) between 46%-52% and serologically active clinically quiescent (SACQ) disease ranging from 6 to 15%. Our goal was to evaluate the flare, PAD and SACQ rate incidence in a cohort of SLE patients over a 2-year follow-up.
We evaluated 394 SLE patients. Flare was defined as an increase in SLEDAI-2K score of ≥4 from the previous visit; PAD was defined as a SLEDAI-2K score of ≥4, on >2 consecutive visits; SACQ was defined as at least a 2-year period without clinical activity and with persistent serologic activity.
Among the 95 patients eligible for the analysis in 2009, 7 (7.3%) had ≥1 flare episode, whereas 9 (9.4%) had PAD. Similarly, among the 118 patients selected for the analysis in 2010, 6 (5%) had ≥1 flare episode, whereas 16 (13.5%) had PAD. Only 1/45 patient (2.2%) showed SACQ during the follow-up.
We showed a low incidence of flare, PAD and SACQ in Italian SLE patients compared with previous studies which could be partly explained by ethnic differences.
已有多项指标被提议用于评估系统性红斑狼疮（SLE）患者的疾病活动度。最近的研究显示，狼疮发作的发生率为 28-35.3%，持续性活动疾病（PAD）为 46%-52%，血清学活动但临床静止（SACQ）疾病为 6-15%。我们的目的是评估 SLE 患者在 2 年随访期间的发作、PAD 和 SACQ 发生率。
我们评估了 394 例 SLE 患者。狼疮发作定义为与前一次就诊相比，SLEDAI-2K 评分增加≥4 分；PAD 定义为 SLEDAI-2K 评分≥4 分，且连续两次就诊均≥4 分；SACQ 定义为至少 2 年无临床活动且持续存在血清学活动。
在 2009 年符合分析条件的 95 例患者中，有 7 例（7.3%）有≥1 次发作，有 9 例（9.4%）有 PAD。同样，在 2010 年符合分析条件的 118 例患者中，有 6 例（5%）有≥1 次发作，有 16 例（13.5%）有 PAD。只有 1/45 例患者（2.2%）在随访期间出现 SACQ。
与之前的研究相比，意大利 SLE 患者的发作、PAD 和 SACQ 发生率较低，这可能部分归因于种族差异。
