The Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Tel Hashomer, Israel.
Autoimmun Rev. 2012 Jun;11(8):593-5. doi: 10.1016/j.autrev.2011.10.020. Epub 2011 Oct 25.
Systemic lupus erythematosus (SLE) characterizes by a variety of clinical manifestations and the presence of a wide profile of autoantibodies. This clinical and serological heterogeneity raised the question: is SLE a single disease with varied phenotypes, or a similar phenotype shared by different diseases with diverse pathogenic mechanisms? Herein we debate the clinical, genetic, hormonal and serological differences typically observed in SLE on the one hand, and the numerous similarities between subtypes of this disease on the other. Leading to the conclusion that SLE may be considered not as a single disease but rather as a single syndrome, which defines by a set of signs, symptoms, or phenomena that occur together and suggest a particular abnormality. Additionally, the accumulated knowledge on gene expression pathways, autoantibodies clusters, hormonal and environmental factors associated with SLE may allow a better classification of this syndrome and updating of SLE criteria. This may further allow targeted biologics and other therapies as well as "personalized medicine" to begin.
系统性红斑狼疮（SLE）的特征是多种临床表现和广泛的自身抗体谱。这种临床和血清学的异质性提出了一个问题：SLE 是一种具有不同表型的单一疾病，还是一种具有不同发病机制的不同疾病所共有的相似表型？在这里，我们一方面讨论了 SLE 中通常观察到的临床、遗传、激素和血清学差异，另一方面也讨论了该疾病亚型之间的许多相似之处。得出的结论是，SLE 可能不被视为一种单一的疾病，而是一种单一的综合征，它由一组共同出现并提示特定异常的体征、症状或现象定义。此外，关于与 SLE 相关的基因表达途径、自身抗体簇、激素和环境因素的累积知识，可能允许对这种综合征进行更好的分类，并更新 SLE 标准。这可能进一步允许针对生物制剂和其他疗法以及“个性化医疗”的开始。
