血清学活跃但临床静止的系统性红斑狼疮——临床病情复发的预测因素
Serologically active clinically quiescent systemic lupus erythematosus--predictors of clinical flares.
作者信息
Walz LeBlanc B A, Gladman D D, Urowitz M B
机构信息
Lupus Clinic, Wellesley Hospital, Toronto, ON, Canada.
出版信息
J Rheumatol. 1994 Dec;21(12):2239-41.
OBJECTIVE
To identify the frequency of serologic activity in the face of clinical quiescence in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively in a single center.
METHODS
In a prospective cohort study, patients serologically active but clinically quiescent (SACQ) in 3 consecutive clinic visits were analyzed for the development of a clinical flare over the subsequent year and were evaluated for predictive factors for flare before and during their SACQ period.
RESULTS
Forty-six episodes of SACQ went on to clinical flare within one year while 60 did not. No predictive factors for flare were found either during or before the SACQ period.
CONCLUSIONS
A significant population of patients with SLE are SACQ and must be followed over time and treated only on the basis of clinical criteria.
目的
在一个单中心前瞻性随访的大型系统性红斑狼疮（SLE）患者队列中，确定临床静止期血清学活动的频率。
方法
在一项前瞻性队列研究中，对连续3次门诊就诊时血清学活动但临床静止（SACQ）的患者进行分析，观察其后一年临床病情复发情况，并评估SACQ期之前及期间病情复发的预测因素。
结果
46例SACQ患者在一年内出现临床病情复发，60例未复发。在SACQ期期间或之前均未发现病情复发的预测因素。
结论
相当一部分SLE患者处于SACQ状态，必须长期随访，且仅根据临床标准进行治疗。
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