Brotman D N, Flancbaum L, Kang Y H, Merrill G F, Fisher H
Department of Surgery, University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick.
Crit Care Med. 1990 Mar;18(3):317-21. doi: 10.1097/00003246-199003000-00015.
Carcinine (beta-alanylhistamine) is a recently discovered compound that is present in the hearts of several mammalian species, including man. Although the function of carcinine is unknown, its structural similarity to histamine, a compound known to have profound effects on the mammalian heart, and to carnosine (beta-alanylhistidine), a compound which we have previously shown to serve as a histamine source, led to the hypothesis that carcinine may play a role in mammalian cardiac physiology. We therefore administered several doses of carcinine (10, 25, 50, 75, and 100 micrograms) to isolated, perfused guinea pig hearts in a Langendorff apparatus. Carcinine exerted a dose-dependent positive inotropic effect, similar to that of histamine. Comparable doses of carnosine yielded no measurable change in contractility. We conclude that carcinine appears to be a positive inotrope in the mammalian heart, and may play a role in cardiac physiology via its metabolic link to histamine.
肌肽（β-丙氨酰组胺）是一种最近发现的化合物，存在于包括人类在内的几种哺乳动物的心脏中。尽管肌肽的功能尚不清楚，但其结构与组胺（一种已知对哺乳动物心脏有深远影响的化合物）以及与肌肽（β-丙氨酰组氨酸，我们之前已证明其可作为组胺来源的化合物）相似，这使得人们推测肌肽可能在哺乳动物心脏生理学中发挥作用。因此，我们在Langendorff装置中，给离体灌注的豚鼠心脏注射了几剂肌肽（10、25、50、75和100微克）。肌肽产生了剂量依赖性的正性肌力作用，类似于组胺。同等剂量的肌肽对收缩性没有可测量的影响。我们得出结论，肌肽似乎是哺乳动物心脏中的一种正性肌力物质，并且可能通过其与组胺的代谢联系在心脏生理学中发挥作用。
