Department of Biomedical Sciences and Technologies, University of l'Aquila, l'Aquila, Italy.
Nat Prod Res. 2013;27(17):1528-31. doi: 10.1080/14786419.2012.730043. Epub 2012 Oct 2.
The in vitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 µg mL(-1) for sphaerophorin to 1024 µg mL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.
从智利南部（包括南极洲）采集的八种地衣分离物的体外抗菌活性，对耐甲氧西林的金黄色葡萄球菌、溶血性葡萄球菌和华纳葡萄球菌的临床分离株进行了评估。通过微量稀释法计算的最小抑菌浓度范围为 8μg/mL 的球孢菌素到 1024μg/mL 的富马酸原贝壳杉烯酸。然而，这些发现表明，地衣中的天然化合物是鉴定新型模板的良好候选物，可用于开发新的抗菌药物或化疗药物组合。
