从地钱中分离出的偏诺卡酸对耐甲氧西林 的抗菌活性。
Antimicrobial Activity of Divaricatic Acid Isolated from the Lichen against Methicillin-Resistant .
机构信息
Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Department of Agricultural Chemistry, Sunchon National University, Suncheon 57922, Korea.
出版信息
Molecules. 2018 Nov 23;23(12):3068. doi: 10.3390/molecules23123068.
One hundred and seventy seven acetone extracts of lichen and 258 ethyl acetate extracts of cultured lichen-forming fungi (LFF) were screened for antimicrobial activity against and using a disk diffusion method. Divaricatic acid was isolated from and identified by LC-MS, ¹H-, C- and DEPT-NMR. Purified divaricatic acid was effective against Gram + bacteria, such as , , , and , with the minimum inhibitory concentration (MIC) values ranging from 7.0 to 64.0 μg/mL, whereas vancomycin was effective in the MICs ranging from 0.78 to 25.0 μg/mL. Interestingly, the antibacterial activity of divaricatic acid was higher than vancomycin against and , and divaricatic acid was active against . In addition, divaricatic acid was active as vancomycin against (3A048; an MRSA). These results suggested that divaricatic acid is a potential antimicrobial agent for the treatment of MRSA infections.
一百七十七份地衣的丙酮提取物和二百五十八份培养的地衣形成真菌（LFF）的乙酸乙酯提取物被筛选出来，以对抗 和 使用圆盘扩散法进行抗菌活性筛选。分裂酸是从 中分离出来的，并通过 LC-MS、1H-NMR、C-NMR 和 DEPT-NMR 进行鉴定。纯化的分裂酸对革兰氏阳性菌，如 、 、 、 和 具有活性，最小抑菌浓度（MIC）值范围为 7.0 至 64.0 μg/mL，而万古霉素在 MIC 范围为 0.78 至 25.0 μg/mL 时有效。有趣的是，分裂酸对 和 的抗菌活性高于万古霉素，并且分裂酸对 也有活性。此外，分裂酸对万古霉素具有活性，对 （3A048；MRSA）也有活性。这些结果表明，分裂酸是治疗耐甲氧西林金黄色葡萄球菌感染的潜在抗菌剂。
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