Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, 90127 Palermo, Italy.
Atherosclerosis. 2012 Nov;225(1):216-9. doi: 10.1016/j.atherosclerosis.2012.08.027. Epub 2012 Sep 13.
We conducted a study to evaluate arterial stiffness markers in subjects with acute ischemic stroke and metabolic syndrome and in relation to TOAST subtype of stroke. We enrolled 130 patients with acute ischemic stroke and metabolic syndrome, 127 patients with acute ischemic stroke without metabolic syndrome and 120 control subjects without acute stroke. Applanation tonometry to record pulse wave velocity (PWV). Stroke patients with metabolic syndrome, compared control subjects without stroke showed higher PWV. In subjects with ischemic stroke and metabolic syndrome, PWV was more significantly and positively correlated with body mass index, systolic blood pressure, hypertension, diabetes, glucose blood levels, LDL cholesterol levels, total cholesterol levels, micro-albuminuria, carotid plaque, previous brain infarct at neuro-imaging. Our findings underline important role of both small vessel disease and atherosclerosis on arterial stiffness pathogenesis in the clinical setting of metabolic syndrome.
我们进行了一项研究，评估了急性缺血性脑卒中合并代谢综合征患者以及与 TOAST 亚型脑卒中相关的动脉僵硬度标志物。我们纳入了 130 例急性缺血性脑卒中合并代谢综合征患者、127 例急性缺血性脑卒中无代谢综合征患者和 120 例无急性脑卒中的对照患者。使用平板张力法记录脉搏波速度（PWV）。与无脑卒中的对照患者相比，代谢综合征的脑卒中患者 PWV 更高。在缺血性脑卒中合并代谢综合征患者中，PWV 与体重指数、收缩压、高血压、糖尿病、血糖水平、LDL 胆固醇水平、总胆固醇水平、微量白蛋白尿、颈动脉斑块、神经影像学上的既往脑梗死呈更显著和正相关。我们的研究结果强调了在代谢综合征的临床环境中，小血管疾病和动脉粥样硬化对动脉僵硬度发病机制的重要作用。
