Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, P.zza delle Cliniche n.2, 90127 Palermo, Italy.
Atherosclerosis. 2010 Jul;211(1):187-94. doi: 10.1016/j.atherosclerosis.2010.02.010. Epub 2010 Feb 18.
No study has evaluated both arterial stiffness indexes (PWV and Aix) in patients with an acute cerebrovascular event. The aim of our study was to evaluate arterial stiffness indexes in subjects with acute ischemic stroke and to evaluate the relationship between these indexes and other clinical and laboratory variables.
We enrolled all consecutive patients with a diagnosis of acute ischemic stroke admitted to the Internal Medicine Department at the University of Palermo between November 2006 and January 2009, and hospitalized control patients without a diagnosis of acute ischemic stroke. The type of acute ischemic stroke was classified according to the TOAST classification. Carotid-femoral pulse wave velocity (PWV) was evaluated by Applanation tonometry (SphygmoCor) and the aortic pressure waveform was used to calculate the Augmentation index (Aix).
We enrolled 107 patients with acute ischemic stroke and 102 control subjects matched for age, sex, cardiovascular risk factors and previous cardiovascular morbidity. Stroke patients, compared to subjects without acute ischemic stroke, showed a higher mean Aix (103+/-3.5 mmHg vs. 99+/-4.6 mmHg) and PWV (11.8+/-3.3 m/s vs. 10.02+/-2.29 m/s). Augmentation Index and PWV values in lacunar subjects were significantly higher compared to values observed in LAAS, CEI and subtypes.
Our study shows that patients with acute ischemic stroke show higher arterial stiffness index values. Among stroke patients, lacunar subtype has the highest arterial stiffness indexes. This finding underlines previous data regarding the strict association between hypertension and diabetes and arterial stiffness, owing the higher percentage of hypertensive and diabetic subjects in the lacunar group.
尚无研究同时评估急性脑血管事件患者的动脉僵硬度指标（脉搏波速度和 Aix）。我们的研究旨在评估急性缺血性脑卒中患者的动脉僵硬度指标，并评估这些指标与其他临床和实验室变量之间的关系。
我们纳入了 2006 年 11 月至 2009 年 1 月期间在巴勒莫大学内科部门住院的所有连续诊断为急性缺血性脑卒中的患者，并纳入了无急性缺血性脑卒中诊断的住院对照患者。急性缺血性脑卒中的类型根据 TOAST 分类进行分类。通过平板张力法（SphygmoCor）评估颈-股脉搏波速度（PWV），并使用主动脉压力波形计算增强指数（Aix）。
我们纳入了 107 例急性缺血性脑卒中患者和 102 例年龄、性别、心血管危险因素和既往心血管疾病史相匹配的对照患者。与无急性缺血性脑卒中的患者相比，脑卒中患者的平均 Aix（103±3.5mmHg 比 99±4.6mmHg）和 PWV（11.8±3.3m/s 比 10.02±2.29m/s）更高。腔隙性患者的 Aix 和 PWV 值明显高于 LAAS、CEI 和亚型的患者。
我们的研究表明，急性缺血性脑卒中患者的动脉僵硬度指标值较高。在脑卒中患者中，腔隙性亚型的动脉僵硬度指标最高。这一发现强调了高血压和糖尿病与动脉僵硬度之间的密切关联，因为腔隙性组中高血压和糖尿病患者的比例更高。
