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Sensitive detection assays for influenza RNA do not reveal viremia in US blood donors.流感 RNA 的敏感检测方法并未在美血液捐献者中发现病毒血症。
J Infect Dis. 2012 Mar 15;205(6):886-94. doi: 10.1093/infdis/jir863. Epub 2012 Jan 31.
2
Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia.2009年甲型H1N1流感大流行病毒肺炎住院成人的病毒清除及炎症反应模式
Antivir Ther. 2011;16(2):237-47. doi: 10.3851/IMP1722.
3
No viremia of pandemic (H1N1) 2009 was demonstrated in blood donors who had donated blood during the probable incubation period.在可能的潜伏期内献血的献血者的血液中未检测到大流行 (H1N1) 2009 的病毒血症。
Transfusion. 2011 Sep;51(9):1949-56. doi: 10.1111/j.1537-2995.2011.03109.x. Epub 2011 Mar 17.
4
Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients.造血干细胞移植受者 2009 年甲型 H1N1 流感和季节性流感后临床结局的差异。
Blood. 2011 May 12;117(19):5050-6. doi: 10.1182/blood-2010-11-319186. Epub 2011 Mar 3.
5
Respiratory failure caused by 2009 novel influenza A/H1N1 in a hematopoietic stem-cell transplant recipient: Detection of extrapulmonary H1N1 RNA and use of intravenous peramivir.一名造血干细胞移植受者因2009年甲型H1N1新型流感导致的呼吸衰竭：肺外H1N1 RNA的检测及静脉注射帕拉米韦的应用
Ann Intern Med. 2010 May 4;152(9):619-20. doi: 10.7326/0003-4819-152-9-201005040-00022.
6
Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCT.造血细胞移植（HCT）后呼吸病毒肺炎：支气管肺泡灌洗液样本中病毒载量、血清样本中病毒 RNA 检测与 HCT 临床结局之间的关系。
J Infect Dis. 2010 May 1;201(9):1404-13. doi: 10.1086/651662.
7
Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses.H1N1、H5N1 和 H3N2 流感病毒所致病理学的比较。
Arch Med Res. 2009 Nov;40(8):655-61. doi: 10.1016/j.arcmed.2009.10.001. Epub 2010 Jan 6.
8
H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment.甲型 H1N1 流感病毒相关性急性肺损伤：奥司他韦联合长期皮质类固醇治疗的反应。
Intensive Care Med. 2010 Jan;36(1):33-41. doi: 10.1007/s00134-009-1727-6. Epub 2009 Nov 19.
9
Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients.造血细胞移植受者中呼吸道病毒的传统检测与分子检测比较
Transpl Infect Dis. 2009 Aug;11(4):298-303. doi: 10.1111/j.1399-3062.2009.00400.x. Epub 2009 May 11.
10
Influenza viremia and the potential for blood-borne transmission.流感病毒血症及血源性传播的可能性。
Transfusion. 2007 Jun;47(6):1080-8. doi: 10.1111/j.1537-2995.2007.01264.x.

血液中流感病毒 RNA 的检测可作为预测造血细胞移植受者疾病严重程度的标志物。

Influenza viral RNA detection in blood as a marker to predict disease severity in hematopoietic cell transplant recipients.

机构信息

Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

出版信息

J Infect Dis. 2012 Dec 15;206(12):1872-7. doi: 10.1093/infdis/jis610. Epub 2012 Oct 2.

DOI:10.1093/infdis/jis610
PMID:23033148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3502377/
Abstract

Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus seasonal strains). Viremia increased the risk of progression to lower respiratory tract disease (LRD), hypoxemia, respiratory failure, and overall and influenza-related death. Among patients with LRD, viremia was associated with increased hazards of overall and influenza-associated death (hazard ratio 3.5, 1.1-12). Thus, influenza viremia may serve as marker for overall poor outcome.

摘要

血液中的流感 RNA（病毒血症）在 79 例流感造血细胞移植受者中检测到 9 例（11.4%），仅在上呼吸道疾病患者中较少观察到，在感染 2009 年大流行流感 A/H1N1 株（与季节性株相比）的患者中更常观察到。病毒血症增加了进展为下呼吸道疾病（LRD）、低氧血症、呼吸衰竭以及总体和流感相关死亡的风险。在患有 LRD 的患者中，病毒血症与总体和与流感相关的死亡风险增加相关（风险比 3.5，1.1-12）。因此，流感病毒血症可能是总体不良预后的标志物。