Hart W M, Silverman S E, Trick G L, Nesher R, Gordon M O
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110.
Invest Ophthalmol Vis Sci. 1990 Feb;31(2):359-67.
Using a modified Humphrey perimeter, we evaluated 16 eyes with primary open-angle glaucoma and visual field loss (defects 0.5-3.0 log units in depth), and 14 normal eyes. Each eye was tested twice in random order with conventional luminance-increment static perimetry and with the perimeter modified to produce a high-luminance yellow adapting background and a blue test stimulus. The background was a broad-spectrum light of 500 nm and above (yellow), while the stimulus was a broad-spectrum light of 500 nm and below (blue). Paired comparisons were made between conventional and blue/yellow sensitivities for every point examined (1184 points in 16 diseased eyes and 1036 points in 14 normal eyes). Defect depths were determined by using the age-corrected norms distributed in the Humphrey Statpac software. In glaucomatous eyes, blue/yellow sensitivity showed greater impairment than did conventional perimetric sensitivity, in which defect depths were less than 1.0 log unit. However, for defects greater than 1.0 log unit in depth, conventional perimetric sensitivity and blue/yellow sensitivity showed equivalent degrees of damage. Receiver operating characteristic (ROC) analysis was used to compare the ability of blue/yellow and of conventional perimetry in distinguishing between glaucomatous and normal eyes. Results indicated that although blue/yellow color-contrast perimetry may be more sensitive for the detection of incipient glaucomatous damage, in the manifest stages of visual field damage blue/yellow color-contrast perimetry is no more sensitive than is conventional (luminance-increment) perimetry for defining the extent of glaucomatous visual field defects.
我们使用改良的汉弗莱视野计，对16只患有原发性开角型青光眼且有视野缺损（缺损深度为0.5 - 3.0对数单位）的眼睛以及14只正常眼睛进行了评估。每只眼睛均按照随机顺序，分别采用传统的亮度增量静态视野检查法，以及经过改良以产生高亮度黄色适应背景和蓝色测试刺激的视野计进行了两次测试。背景光是波长500纳米及以上的广谱光（黄色），而刺激光是波长500纳米及以下的广谱光（蓝色）。对每一个检查点（16只患病眼睛中的1184个点以及14只正常眼睛中的1036个点）的传统敏感度和蓝/黄敏感度进行了配对比较。缺损深度通过使用汉弗莱Statpac软件中分布的年龄校正正常值来确定。在青光眼眼中，对于缺损深度小于1.0对数单位的情况，蓝/黄敏感度比传统视野检查敏感度受损更严重。然而，对于深度大于1.0对数单位的缺损，传统视野检查敏感度和蓝/黄敏感度显示出同等程度的损害。采用接受者操作特征（ROC）分析来比较蓝/黄视野检查法和传统视野检查法区分青光眼和正常眼睛的能力。结果表明，尽管蓝/黄颜色对比视野检查法在检测早期青光眼损害时可能更敏感，但在视野损害的明显阶段，蓝/黄颜色对比视野检查法在界定青光眼视野缺损范围方面并不比传统（亮度增量）视野检查法更敏感。
