Falcão-Reis F, O'Donoghue E, Buceti R, Hitchings R A, Arden G B
Department of Clinical Ophthalmology, Moorfields Eye Hospital, London.
Br J Ophthalmol. 1990 Dec;74(12):712-6. doi: 10.1136/bjo.74.12.712.
Contrast sensitivity has been measured in patients with glaucoma and ocular hypertension, the latter graded into high, medium, and low risk clinical groups. Measurements were made centrally and peripherally at 10 degrees, 15 degrees, 20 degrees, and 25 degrees off-axis at each of the four meridians 45 degrees, 135 degrees, 225 degrees, and 315 degrees. A sine wave grating of 1.9 cycles/degree, reversing at 1 Hz was used. It was displayed on a 100-Hz refresh rate monitor. Normal values were established to compare those from 41 eyes from patients with either primary open angle glaucoma (POAG) with minimal field loss detectable on a Humphrey perimeter, or raised IOP and/or disc changes but no field loss (OH). Those with POAG had normal central contrast sensitivity, but at 20 degrees and 25 degrees eccentricity the values were greater than 2 standard deviations above the normal mean. This was also the case for high risk OH, but not for low risk patients. All the high risk patients except one who had abnormal peripheral contrast sensitivity had possible field defects (threshold elevation at one or more points more than 5 but less than 10 dB above normal mean). Only one of those with normal peripheral contrast sensitivity had such 'suspect points'. The results are assessed in terms of screening of glaucoma suspects.
已对青光眼和高眼压症患者进行了对比敏感度测量，后者被分为高、中、低风险临床组。测量在四个子午线（45度、135度、225度和315度）上离轴10度、15度、20度和25度的中央和周边进行。使用了1.9周/度、以1赫兹反转的正弦波光栅。它显示在刷新率为100赫兹的监视器上。建立了正常值，以比较41只眼睛的测量值，这些眼睛来自原发性开角型青光眼（POAG）患者，其在汉弗莱视野计上可检测到最小的视野缺损，或眼压升高和/或视盘改变但无视野缺损（高眼压症，OH）。POAG患者的中央对比敏感度正常，但在偏心率为20度和25度时，其值高于正常平均值2个标准差以上。高风险OH患者也是如此，但低风险患者并非如此。除一名外周对比敏感度异常的患者外，所有高风险患者都有可能存在视野缺损（在一个或多个点上阈值升高超过正常平均值5但小于10分贝）。外周对比敏感度正常的患者中只有一人有这样的“可疑点”。根据青光眼可疑患者的筛查对结果进行了评估。
