Pierzynowski S G, Weström B R, Svendsen J, Karlsson B W
Department of Zoophysiology, University of Lund, Sweden.
J Pediatr Gastroenterol Nutr. 1990 Feb;10(2):206-12. doi: 10.1097/00005176-199002000-00011.
The development of exocrine pancreas function was studied in Swedish Landrace pigs surgically fitted with a chronic pancreatic duct catheter and a duodenal re-entrant cannula. The juice secretion and output of total protein and trypsin activity were followed before (basal secretion) and after feeding (postprandial secretion) during the first 1-13 weeks of life. The results showed that throughout the suckling period, up to 4-5 weeks of age, the basal pancreas function remained low and the secretory response to feeding, i.e., nursing sow milk, was also low. After weaning, the pancreatic juice secretion as well as the output of protein and trypsin activity markedly increased with respect to both basal and postprandial levels. Furthermore, the enzyme composition of the pancreatic juice changed qualitatively during this period. During the first 2 weeks of life, the intravenous administration of cholecystokinin (CCK) and secretin did not stimulate exocrine function, but a significant effect was achieved from 3-4 weeks of age. These results showed that there was both an increase in exocrine pancreas function and a qualitative change in the hydrolytic enzyme pattern during porcine postnatal ontogeny, apparently correlated with the changes in diet around weaning. An increase in the response of the pancreas to hormonal stimulation was also observed during the suckling period.
对通过手术安装了慢性胰管导管和十二指肠再入式插管的瑞典长白猪的外分泌胰腺功能发育进行了研究。在出生后的第1至13周内，分别在喂食前（基础分泌）和喂食后（餐后分泌）跟踪胰液分泌、总蛋白输出量和胰蛋白酶活性。结果表明，在整个哺乳期，直至4至5周龄，基础胰腺功能保持较低水平，对喂食（即哺乳母猪的乳汁）的分泌反应也较低。断奶后，胰液分泌以及蛋白质和胰蛋白酶活性的输出量相对于基础水平和餐后水平均显著增加。此外，在此期间胰液的酶组成发生了质的变化。在出生后的前2周内，静脉注射胆囊收缩素（CCK）和促胰液素并未刺激外分泌功能，但从3至4周龄开始产生显著效果。这些结果表明，在猪出生后的个体发育过程中，外分泌胰腺功能增加，水解酶模式发生质的变化，这显然与断奶前后饮食的变化相关。在哺乳期还观察到胰腺对激素刺激的反应有所增加。
