Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad 380 009, Gujarat, India.
Eur J Pharmacol. 2012 Dec 15;697(1-3):1-12. doi: 10.1016/j.ejphar.2012.09.034. Epub 2012 Oct 4.
The present review shall familiarize the readers with the role of renin-angiotensin aldosterone system (RAAS), which regulates blood pressure, electrolyte and fluid homeostasis. The local RAAS operates in an autocrine, paracrine and/or intracrine manner and exhibits multiple physiological effects at the cellular level. In addition to local RAAS, there exists a complete pancreatic RAAS which has multi-facet role in diabetes and cardiovascular diseases. Aldosterone is known to mediate hyperinsulinemia, hypertension, cardiac failure and myocardial fibrosis while angiotensin II mediates diabetes, endothelial dysfunction, vascular inflammation, hypertrophy and remodeling. As the understanding of this biology of RAAS increases, it serves to exploit this for the pharmacotherapy of diabetes and cardiovascular diseases.
本综述将使读者熟悉肾素-血管紧张素-醛固酮系统（RAAS）的作用，该系统调节血压、电解质和液体平衡。局部 RAAS 以自分泌、旁分泌和/或胞内方式发挥作用，并在细胞水平表现出多种生理效应。除了局部 RAAS 外，还存在一个完整的胰腺 RAAS，它在糖尿病和心血管疾病中具有多方面的作用。醛固酮已知可介导高胰岛素血症、高血压、心力衰竭和心肌纤维化，而血管紧张素 II 则介导糖尿病、内皮功能障碍、血管炎症、肥大和重塑。随着对 RAAS 生物学的理解不断增加，它可以为糖尿病和心血管疾病的药物治疗提供依据。
