Lekili M, Tekgül S, Ergen A, Taşar C, Hasçelik G
Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
Int Urol Nephrol. 1992;24(3):291-7. doi: 10.1007/BF02549538.
We examined the nature of contralateral damage following unilateral orchitis to see if an immunologically mediated mechanism was present. Experimentally induced orchitis in 18 white New Zealand rabbits were examined and compared to 20 in the control groups. Serum antisperm antibody presence and bilateral testicular biopsies (Johansen biopsy score, mean seminiferous tubule diameter) were examined and pregnancy rates were noted. Acute orchitis seemed to be a causative factor in production of antisperm antibody and the presence of antisperm antibody caused histologic changes in contralateral testicles and therefore impaired fertility.
我们研究了单侧睾丸炎后对侧损伤的性质，以确定是否存在免疫介导机制。对18只实验诱导患睾丸炎的新西兰白兔进行了检查，并与20只对照组兔子进行比较。检测血清抗精子抗体的存在情况以及双侧睾丸活检结果（约翰森活检评分、生精小管平均直径），并记录受孕率。急性睾丸炎似乎是产生抗精子抗体的一个致病因素，而抗精子抗体的存在会导致对侧睾丸出现组织学变化，从而损害生育能力。
