Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea.
Opt Lett. 2012 Sep 15;37(18):3894-6. doi: 10.1364/ol.37.003894.
The microjet injector system accelerates drugs and delivers them without a needle, which is shown to overcome the weaknesses of existing jet injectors. A significant increase in the delivered dose of drugs is reported with multiple pulses of laser beam at lower laser energy than was previously used in a Nd:YAG system. The new injection scheme uses the beam wavelength best absorbable by water at a longer pulse mode for elongated microjet penetration into a skin target. A 2.9 μm Er:YAG laser at 250 μs pulse duration is used for fluorescent staining of guinea pig skin and for injection controllability study. Hydrodynamic theory confirms the nozzle exit jet velocity obtained by the present microjet system.
微喷射注射器系统无需针头即可加速药物输送，据称克服了现有喷射注射器的弱点。与以前在 Nd:YAG 系统中使用的激光能量相比，通过多次激光束脉冲可以显著增加药物的输送剂量。新的注射方案使用最能被水吸收的光束波长，在较长的脉冲模式下，使微喷射延长穿透皮肤靶标。2.5 μs 脉冲持续时间的 2.9μmEr:YAG 激光用于豚鼠皮肤的荧光染色和注射可控性研究。流体动力学理论证实了本微喷射系统获得的喷嘴出口射流速度。
