Department of Medicine, McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
Semin Thromb Hemost. 2012 Oct;38(7):673-82. doi: 10.1055/s-0032-1326782. Epub 2012 Oct 6.
D-dimer is a global indicator of coagulation activation and fibrinolysis and, therefore, an indirect marker of thrombotic activity. The utility of D-dimer measurement has been evaluated in several clinical situations including the exclusion of venous thromboembolism (VTE), prediction of future risk of VTE, and the diagnosis and monitoring of disseminated intravascular coagulation (DIC). Assay standardization remains problematic and clinicians need to be aware of variability in D-dimer assay performance and the characteristics of their institution's test when making clinical decisions. This article will review the available evidence for the utilization of D-dimer antigen measurement in the management of thrombotic and bleeding disorders.
D-二聚体是凝血激活和纤维蛋白溶解的全局指标，因此是血栓形成活性的间接标志物。D-二聚体测量的实用性已在几种临床情况下进行了评估，包括排除静脉血栓栓塞症（VTE）、预测未来 VTE 风险以及弥散性血管内凝血（DIC）的诊断和监测。检测标准化仍然存在问题，临床医生在做出临床决策时需要了解 D-二聚体检测性能的可变性及其所在机构检测的特点。本文将回顾 D-二聚体抗原测量在血栓和出血性疾病管理中的应用的现有证据。
