Rossi F W, Prevete N, Montuori N, Ragno P, Selleri C, Marone G, de Paulis A
Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research, University of Naples Federico II and Istituto Zooprofilattico Sperimentale del Mezzogiorno, Italy.
Infez Med. 2012;20 Suppl 2:19-25.
Helicobacter pylori (H. pylori) is a microaerophilic, Gram-negative bacterium that affects more than half of the world's population. H. pylori has co-evolved with humans to be transmitted from person to person and to persistently colonize the stomach. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases. During its long coexistence with humans, H. pylori has evolved complex strategies to limit the degree and extent of gastric mucosal damage and inflammation as well as immune effector activity. In this complex strategy an important role is played by the interaction of H. pylori with a specific class of innate immune receptors, named N-formyl peptide receptor family (FPRs). In the last years several virulence factors have been studied in an effort to correlate bacterial phenotype with specific gastric manifestations and to clarify the pathogenetic mechanisms. Several peptides produced by H. pylori appear to be involved in inflammation associated with the infection. A particular interest has been focused on the Hp(2-20) peptide derived from the bacteria. Thus, aim of the article is to comment on some advances in the elucidation of specific interactions between the Hp(2-20) peptide and FPRs.
幽门螺杆菌（H. pylori）是一种微需氧的革兰氏阴性菌，全球超过一半的人口都受其影响。幽门螺杆菌与人类共同进化，可在人与人之间传播，并持续定植于胃部。细菌效应分子与宿主反应之间精心编排的平衡使得微生物能够持续存在且宿主保持健康，但也带来了患严重疾病的风险。在与人类长期共存的过程中，幽门螺杆菌进化出了复杂的策略来限制胃黏膜损伤和炎症的程度及范围，以及免疫效应活性。在这一复杂策略中，幽门螺杆菌与一类特定的天然免疫受体，即N-甲酰肽受体家族（FPRs）的相互作用发挥了重要作用。近年来，人们对几种毒力因子进行了研究，试图将细菌表型与特定的胃部表现相关联，并阐明发病机制。幽门螺杆菌产生的几种肽似乎与感染相关的炎症有关。人们对源自该细菌的Hp(2 - 20)肽尤为关注。因此，本文的目的是对Hp(2 - 20)肽与FPRs之间特定相互作用的阐明方面的一些进展进行评论。
