幽门螺杆菌的持续存在：生物学与疾病
Helicobacter pylori persistence: biology and disease.
作者信息
Blaser Martin J, Atherton John C
机构信息
Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA.
出版信息
J Clin Invest. 2004 Feb;113(3):321-33. doi: 10.1172/JCI20925.
Abstract
Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.
摘要
幽门螺杆菌是一种与人类共同进化的细菌，可在人与人之间传播，并持续定植于胃部。它们的种群结构是研究本土微生物群生态学的一个模型。细菌效应物与宿主反应之间精心编排的平衡使得微生物能够持续存在，宿主保持健康，但也带来了包括消化性溃疡和胃肿瘤在内的严重疾病风险。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13579-84. doi: 10.1073/pnas.1735481100. Epub 2003 Oct 30.
2
Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system component.细菌（IV型）分泌系统组件中重复DNA序列的可塑性。
J Exp Med. 2003 Nov 3;198(9):1349-60. doi: 10.1084/jem.20030381. Epub 2003 Oct 27.
3
Protective immunity against Helicobacter is characterized by a unique transcriptional signature.针对幽门螺杆菌的保护性免疫具有独特的转录特征。
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12289-94. doi: 10.1073/pnas.1635231100. Epub 2003 Oct 3.
4
Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori.抗生素根除幽门螺杆菌后耐药肠球菌的长期持续存在。
Ann Intern Med. 2003 Sep 16;139(6):483-7. doi: 10.7326/0003-4819-139-6-200309160-00011.
5
Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation.幽门螺杆菌空泡毒素抑制T淋巴细胞活化。
Science. 2003 Aug 22;301(5636):1099-102. doi: 10.1126/science.1086871.
6
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J Infect Dis. 2003 Aug 15;188(4):486-96. doi: 10.1086/377098. Epub 2003 Jul 31.
7
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Gastroenterology. 2003 Aug;125(2):364-71. doi: 10.1016/s0016-5085(03)00899-0.
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Infect Immun. 2003 Jul;71(7):4163-6. doi: 10.1128/IAI.71.7.4163-4166.2003.
9
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