Toubeau G, Desclin J, Parmentier M, Pasteels J L
Neuroendocrinology. 1979;29(6):374-84. doi: 10.1159/000122948.
By an immunoperoxidase (PAP) technique, ACTH- and prolactin-like substances were detected in neurons of several hypothalamic nuclei in young and adult rats. Neurons in the arcuate and ventromedial nuclei were simultaneously both ACTH-like and PRL-like positive. Labelled fibres were followed to their fields of projections. Intensity of labelling was not influenced by experimental procedures known to change PRL and ACTH content of the pituitary. Colchicine enhanced labelling of perikarya while lowering that of fibres. The results support neuronal synthesis of hormonal ACTH and PRL related molecules and their involvement in the control of autonomic nerve functions.
通过免疫过氧化物酶（PAP）技术，在幼年和成年大鼠的几个下丘脑核的神经元中检测到促肾上腺皮质激素（ACTH）样和催乳素样物质。弓状核和腹内侧核中的神经元同时呈ACTH样和PRL样阳性。追踪标记纤维至其投射区域。标记强度不受已知会改变垂体PRL和ACTH含量的实验程序的影响。秋水仙碱增强了核周体的标记，同时降低了纤维的标记。结果支持激素ACTH和PRL相关分子的神经元合成及其在自主神经功能控制中的作用。
